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Table 1 Effect of antioxidants and polyphenol treatment on acetylcholine-relaxations of mesenteric arteries and corpora cavernosa

From: Protective effect of resveratrol and quercetin on in vitro-induced diabetic mouse corpus cavernosum

 

Mesenteric arteries

Corpora cavernosa

pD2

Emax (%)

pD2

Emax (%)

HG + MGO

HG + MGO + AA

7.1 ± 0.4

7.0 ± 0.2

19.8 ± 2.6

46.8 ± 4.8#

7.8 ± 0.1

7.8 ± 0.2

35.8 ± 6.4

83.5 ± 6.1*

HG + MGO

HG + MGO + Temp

7.0 ± 0.3

7.1 ± 0.1

23.9 ± 5.04

58.3 ± 4.4#

7.7 ± 0.1

7.9 ± 0.2

38.7 ± 4.2

74.3 ± 3.5#

HG + MGO

HG + MGO + Res

6.3 ± 0.9

6.7 ± 0.5

23.2 ± 5.0

34.8 ± 3.7

7.7 ± 0.3

7.6 ± 0.2

47.6 ± 4.3

83.8 ± 4.6#

HG + MGO

HG + MGO + Quer

7.4 ± 1.0

6.7 ± 0.2

24.4 ± 4.4

31.3 ± 6.3

7.9 ± 0.3

7.9 ± 0.02

44.9 ± 3.5

80.0 ± 5.5#

  1. pD2 −log(EC50), E max maximal relaxation response, HG high glucose (30 mM), MGO methylglyoxal (120 µM), AA ascorbic acid (100 µM), Temp tempol (100 µM), Res resveratrol (10 µM for mesenteric arteries, 30 µM for corpora cavernosa), Quer quercetin (3 µM for mesenteric arteries; 30 µM for corpora cavernosa). Data are mean ± SEM. * p < 0.05; #p < 0.01 (compared to HG + MGO group)