Fig. 2

Linkage disequilibrium plot for SNPs in the IRS-1 gene. Linkage disequilibrium between markers was measured by pairwise D’ as calculated from the sample of individuals studied. a Linkage disequilibrium blocks were identified as suggested by the gerbil algorithm. Color support for D’ estimation as reported in the computer program Haploview (Barrett JC et al., 2005). White D’ <1 and LOD <2; shades of pink/red D’ <1 and LOD ≥2; red D’ = 1 and LOD ≥2. Number in the square: D’ value expressed as estimated D’ value × 100; empty square D’ = 1. b Haplotypes with a frequency >5 % in the two linkage disequilibrium blocks