|
DPP4i
|
28,508
|
39.56
|
0.82
|
0.83 (0.76, 0.91)
|
<0.0001
|
|
(ref.=non-DPP4i users)
|
334,148
|
41.53
|
–
|
–
|
–
|
|
Sulfonylureas
|
110,618
|
35.99
|
0.67
|
0.80 (0.77, 0.84)
|
<0.0001
|
|
(ref. = non-sulfonylureas users)
|
252,038
|
43.74
|
–
|
–
|
–
|
|
Acarbose
|
22,800
|
48.37
|
1.01
|
0.92 (0.85, 0.99)
|
0.0463
|
|
(ref. = non-acarbose users)
|
339,856
|
26.10
|
–
|
–
|
–
|
|
Meglitinides
|
13,103
|
102.49
|
2.23
|
1.46 (1.35, 1.58)
|
<0.0001
|
|
(ref. = non-meglitinide users)
|
349,553
|
39.08
|
–
|
–
|
–
|
|
Insulin
|
9632
|
206.06
|
4.75
|
3.53 (3.23, 3.87)
|
<0.0001
|
|
(ref. = non-insulin users)
|
353,024
|
36.88
|
–
|
–
|
–
|
|
Metformin
|
172,813
|
30.87
|
0.48
|
0.66 (0.63, 0.69)
|
<0.0001
|
|
(ref. = non-metformin users)
|
189,843
|
45.00
|
–
|
–
|
–
|
|
Pioglitazone
|
4678
|
24.15
|
0.49
|
0.61 (0.50, 0.75)
|
<0.0001
|
|
(ref. = non-pioglitazone users)
|
357,978
|
41.60
|
–
|
–
|
–
|
|
Rosiglitazone
|
504
|
35.64
|
0.69
|
0.78 (0.49, 1.26)
|
0.3187
|
|
(ref. = non-rosiglitazone users)
|
362,152
|
41.38
|
–
|
–
|
–
|
