Table 3 Top differentially expressed genes in CD34+ cells treated with hyperglycemia–metformin–hypoxia for 3 h versus hyperglycemia–hypoxia
Gene name | Gene symbol | p value | FC |
|---|---|---|---|
Serine/arginine-rich splicing factor 4 | SRSF4 | 3.32E−09 | 1.87 |
Brain expressed, X-linked 4 | BEX4 | 1.43E−07 | 1.76 |
Dihydrouridine synthase 4-like (S. cerevisiae) | DUS4L | 2.41E−07 | 1.60 |
Mitochondrial ribosomal protein S21 | MRPS21 | 2.99E−07 | 1.52 |
Endoplasmic reticulum protein 29 | ERP29 | 6.47E−07 | −1.74 |
Prohibitin | PHB | 1.40E−06 | −1.67 |
Chromosome 11 open reading frame 58 | C11orf58 | 1.48E−06 | 1.91 |
NOP14 nucleolar protein homolog (yeast) | NOP14 | 1.50E−06 | 1.52 |
Deoxynucleotidyltransferase, terminal, interacting protein 1 | DNTTIP1 | 1.97E−06 | 1.91 |
Family with sequence similarity 98, member A | FAM98A | 2.03E−06 | 1.52 |
Dynactin 3 (p22) | DCTN3 | 2.25E−06 | −2.14 |
Solute carrier family 25, member 32 | SLC25A32 | 2.47E−06 | 2.02 |
Heterogeneous nuclear ribonucleoprotein H3 (2H9) | HNRNPH3 | 4.21E−06 | 1.72 |
Glycerol-3-phosphate acyltransferase, mitochondrial | GPAM | 4.31E−06 | −10.76 |
Zinc finger protein 391 | ZNF391 | 4.55E−06 | 1.59 |
Chromosome 11 open reading frame 51 | C11orf51 | 4.61E−06 | 2.36 |
USO1 vesicle docking protein homolog (yeast) | USO1 | 4.64E−06 | 1.55 |
Transducer of ERBB2, 2 | TOB2 | 1.22E−05 | 4.48 |
TIMP metallopeptidase inhibitor 1 | TIMP1 | 3.90E−04 | −1.68 |
Chemokine (C–X–C motif) ligand 10 | CXCL10 | 1.28E−02 | −2.01 |