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Fig. 4 | Cardiovascular Diabetology

Fig. 4

From: Type 2 diabetes enhances arterial uptake of choline in atherosclerotic mice: an imaging study with positron emission tomography tracer 18F-fluoromethylcholine

Fig. 4

18F-FMCH uptake and the density of macrophages in atherosclerotic plaques in diabetic IGF-II/LDLR−/−ApoB100/100 mice. a Macrophage immunostaining (Mac-3, brown) of aortic plaque. The dotted line separates areas of visually high and low macrophage density. Scale bar 100 µm. b Binary image from ImageJ software shows Mac-3-positive staining as black, and the areal percentage of positive staining is measured. c Autoradiograph of the plaque shows high radioactivity co-localizing with the Mac-3-positive staining. d Quantitative uptake of 18F-FMCH in plaque areas with low, intermediate or high areal percentage of Mac-3-positive staining

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Cardiovascular Diabetology

ISSN: 1475-2840