Evaluation of pleiotropic effects among common genetic loci identified for cardio-metabolic traits in a Korean population

Table 3 Evaluation of pleiotropic effect of 12q24.12 (ALDH2, rs671) genotypes

Trait	Effect size(beta ± s.e.)	P value after adjustment for age and sex	After adjustment for an additional covariate
			TG		LDL		HDL		FPG
			Effect size	P value	Effect size	P value	Effect size	P value	Effect size	P value
TG	−7.60 ± 1.72	9.47 × 10⁻⁶	–	–	−4.34 ± 1.18	2.44 × 10⁻⁴	−12.24 ± 1.64	8.41 × 10⁻¹⁴	−6.34 ± 1.68	1.58 × 10⁻⁴
LDL	2.55 ± 0.53	1.53 × 10⁻⁶	2.42 ± 0.54	7.47 × 10⁻⁶	–	–	2.76 ± 0.54	3.24 × 10⁻⁷	2.97 ± 0.56	9.78 × 10⁻⁸
HDL	−1.33 ± 0.18	1.20 × 10⁻¹³	−1.70 ± 0.18	1.80 × 10⁻²¹	−1.53 ± 0.19	8.14 × 10⁻¹⁶	–	–	−1.42 ± 0.19	8.88 × 10⁻¹⁴
FPG	−0.96 ± 0.17	2.00 × 10⁻⁸	−0.96 ± 0.19	2.00 × 10⁻⁷	−1.11 ± 0.18	1.85 × 10⁻⁹	−0.96 ± 0.19	2.38 × 10⁻⁷	–	–
SBP	−1.49 ± 0.32	2.72 × 10⁻⁶	−1.25 ± 0.33	1.37 × 10⁻⁴	−1.45 ± 0.33	1.26 × 10⁻⁵	−1.50 ± 0.33	5.68 × 10⁻⁶	−1.09 ± 0.34	1.14 × 10⁻³
DBP	−0.80 ± 0.21	1.09 × 10⁻⁴	−0.67 ± 0.21	1.41 × 10⁻³	−0.83 ± 0.21	1.03 × 10⁻⁴	−0.90 ± 0.21	2.35 × 10⁻⁵	−0.66 ± 0.22	2.35 × 10⁻³
BMI	−0.16 ± 0.05	2.14 × 10⁻³	−0.11 ± 0.05	2.90 × 10⁻²	−0.20 ± 0.05	1.45 × 10⁻⁴	−0.26 ± 0.05	3.86 × 10⁻⁷	−0.14 ± 0.05	1.14 × 10⁻²
WHR	−0.005 ± 0.001	2.87 × 10⁻⁶	−0.004 ± 0.001	2.81 × 10⁻⁴	−0.005 ± 0.001	1.92 × 10⁻⁵	−0.007 ± 0.001	1.48 × 10⁻¹⁰	−0.004 ± 0.001	3.54 × 10⁻⁴

Trait	Effect size (beta ± s.e.)	P value after adjustment for age and sex	After adjustment for an additional covariate
			SBP		DBP		BMI		WHR
			Effect size	P value	Effect size	P value	Effect size	P value	Effect size	P value
TG	−7.60 ± 1.72	9.47 × 10⁻⁶	−6.89 ± 1.94	3.80 × 10⁻⁴	−6.92 ± 1.93	3.45 × 10⁻⁴	−6.34 ± 1.71	2.14 × 10⁻⁴	−5.71 ± 1.71	8.68 × 10⁻⁴
LDL	2.55 ± 0.53	1.53 × 10⁻⁶	2.66 ± 0.61	1.21 × 10⁻⁵	2.73 ± 0.61	7.29 × 10⁻⁶	2.72 ± 0.54	3.79 × 10⁻⁷	2.57 ± 0.54	2.09 × 10⁻⁶
HDL	−1.33 ± 0.18	1.20 × 10⁻¹³	−1.39 ± 0.19	3.16 × 10⁻¹³	−1.40 ± 0.19	2.87 × 10⁻¹³	−1.54 ± 0.19	1.45 × 10⁻¹⁶	−1.47 ± 0.19	9.01 × 10⁻¹⁵
FPG	−0.96 ± 0.17	2.00 × 10⁻⁸	−0.84 ± 0.20	2.35 × 10⁻⁵	−0.87 ± 0.20	1.20 × 10⁻⁵	−0.91 ± 0.18	6.32 × 10⁻⁷	−0.93 ± 0.19	4.85 × 10⁻⁷
SBP	−1.49 ± 0.32	2.72 × 10⁻⁶	–	–	−0.38 ± 0.19	4.78 × 10⁻²	−1.16 ± 0.32	3.00 × 10⁻⁴	−1.07 ± 0.32	9.21 × 10⁻⁴
DBP	−0.80 ± 0.21	1.09 × 10⁻⁴	−0.07 ± 0.12	0.5869	–	–	−0.63 ± 0.20	2.08 × 10⁻³	−0.57 ± 0.21	5.26 × 10⁻³
BMI	−0.16 ± 0.05	2.14 × 10⁻³	−0.10 ± 0.06	8.72 × 10⁻²	−0.10 ± 0.06	8.47 × 10⁻²	–	–	−0.05 ± 0.05	0.2964
WHR	−0.005 ± 0.001	2.87 × 10⁻⁶	−0.004 ± 0.001	8.28 × 10⁻⁴	−0.004 ± 0.001	7.50 × 10⁻⁴	−0.003 ± 0.001	5.59 × 10⁻⁴	–	–

Total cholesterol was excluded from this analysis. n = 13,378 for all traits except SBP and DBP, where n = 10,310
TG Triglyceride, LDL low density lipoprotein cholesterol, HDL high density lipoprotein cholesterol, FPG fasting plasma glucose, SBP systolic blood pressure, DBP diastolic blood pressure, BMI body mass index, WHR waist-hip ratio, s.e. standard error

ISSN: 1475-2840