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Table 1 Polydatin attenuated serum lipid levels of db/db mice after 4 weeks of polydatin treatment (n = 6–7)

From: Polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating proprotein convertase subtilisin/kexin type 9 (PCSK9)

Group Dose (mg/kg) TC (mmol L−1) TG (mmol L−1) LDL-C (mmol L−1) HDL-C (mmol L−1)
C57   2.18 ± 0.16 1.76 ± 0.26 0.49 ± 0.04 1.05 ± 0.08
db/db   4.06 ± 0.27bbb 2.87 ± 0.89 0.64 ± 0.08bb 1.97 ± 0.23bbb
Polydatin 100 3.24 ± 0.56abb 1.65 ± 0.61a 0.56 ± 0.06a 1.62 ± 0.31abb
Pioglitazone 10 3.89 ± 0.61 1.41 ± 0.23 0.70 ± 0.17 2.07 ± 0.32
  1. Datas are represented as mean ± SD
  2. Serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C), and high-density lipoprotein (HDL-C) of db/db mice were measured after 4 weeks of polydatin treatment (n = 6–7)
  3. a P < 0.05 vs. C57
  4. bb P < 0.01
  5. bbb P < 0.001 vs. db/db