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Table 1 Polydatin attenuated serum lipid levels of db/db mice after 4 weeks of polydatin treatment (n = 6–7)

From: Polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating proprotein convertase subtilisin/kexin type 9 (PCSK9)

Group

Dose (mg/kg)

TC (mmol L−1)

TG (mmol L−1)

LDL-C (mmol L−1)

HDL-C (mmol L−1)

C57

 

2.18 ± 0.16

1.76 ± 0.26

0.49 ± 0.04

1.05 ± 0.08

db/db

 

4.06 ± 0.27bbb

2.87 ± 0.89

0.64 ± 0.08bb

1.97 ± 0.23bbb

Polydatin

100

3.24 ± 0.56abb

1.65 ± 0.61a

0.56 ± 0.06a

1.62 ± 0.31abb

Pioglitazone

10

3.89 ± 0.61

1.41 ± 0.23

0.70 ± 0.17

2.07 ± 0.32

  1. Datas are represented as mean ± SD
  2. Serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C), and high-density lipoprotein (HDL-C) of db/db mice were measured after 4 weeks of polydatin treatment (n = 6–7)
  3. a P < 0.05 vs. C57
  4. bb P < 0.01
  5. bbb P < 0.001 vs. db/db
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Cardiovascular Diabetology

ISSN: 1475-2840