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Fig. 4 | Cardiovascular Diabetology

Fig. 4

From: Polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating proprotein convertase subtilisin/kexin type 9 (PCSK9)

Fig. 4

Polydatin inhibited PCSK9 level and upregulated the protein levels of LDLR and GCK. a, b PCSK9 mRNA and LDLR mRNA levels were detected by quantitative real-time PCR assay. c–e Protein levels of PCSK9, LDLR, and GCK were detected by Western blot analysis in mouse liver as described in “Methods”. Relative fold increases of each protein are shown (mean ± SD, n = 6). f ELISA assay was performed to detect the serum PCSK9 levels according to the manufacture’s instruction. *p < 0.05, **p < 0.01, and ***p < 0.001 vs. db/db

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Cardiovascular Diabetology

ISSN: 1475-2840