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Table 3 Parameters of diastolic function in the fasting state and post meal (pp)

From: Effects of analogue insulin in multiple daily injection therapy of type 2 diabetes on postprandial glucose control and cardiac function compared to human insulin: a randomized controlled long-term study

Parameter MDI insulin regimen At baseline At 36 months p
E’ (cm/s) Analogue
Human
7.8 ± 1.4
8.2 ± 1.7
8.4 ± 1.7
8.2 ± 1.7
0.069
0.738
E’ pp (cm/s) Analogue
Human
7.6 ± 1.6
8.1 ± 1.8
8.5 ± 1.6
8.2 ± 1.8
0.009
0.435
E/A Analogue
Human
0.96 ± 0.3
0.93 ± 0.25
1.11 ± 0.39
1.01 ± 0.30
0.030
0.061
E/A pp Analogue
Human
0.94 ± 0.30
0.92 ± 0.26
1.18 ± 0.46
1.01 ± 0.32
0.005
0.055
E (cm/s) Analogue
Human
70 ± 17
70 ± 20
74 ± 19
72 ± 17
0.296
0.097
E pp (cm/s) Analogue
Human
71 ± 18
74 ± 20
76 ± 21
72 ± 15
0.001
0.068
A (cm/s) Analogue
Human
76 ± 18
75 ± 21
70 ± 19
74 ± 23
0.061
0.368
A pp (cm/s) Analogue
Human
71 ± 18
74 ± 20
68 ± 18
75 ± 22
0.430
0.957
E/E’ (mmHg) Analogue
Human
8.9 {7.5–10.9}
8.1 {7.0–9.6}
8.5 {7–10.3}
8.4 {7.5–10.0}
0.870
0.136
E/E’ pp (mmHg) Analogue
Human
8.3 {7.1–10.1}
8.3 {7.3–9.9}
8.3 {7.2–10.8}
8.1 {7.4–10.8}
0.670
0.203
  1. Italics p values indicate significant changes at 36 months
  2. Mean ± SD or median {interquartile range} respectively
  3. E’ early diastolic myocardial velocity by tissue Doppler, E early diastolic mitral inflow velocity, A late diastolic mitral inflow velocity, E/A ratio of mitral inflow velocities, E/E’ estimated LV filling pressure