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Table 3 Stepwise regression analyses of changes in key study parameters in the HCD group (n = 17)

From: Reduction in peripheral vascular resistance predicts improvement in insulin clearance following weight loss

Dependent variables Step Predictor variables Std.coeff r2 P β
Insulin clearance
 Δ Whole-body insulin clearance (mL m2 min−1) 1 Δ Calf vascular resistance (units) −0.53 0.40 0.01 0.94
2 Δ HDL-cholesterol (mmol/L) 0.40 0.55 0.05  
 Δ Fasting C-peptide to insulin ratio 1 Δ Glucose AUC0-120 (mmol/L/min) −0.63 0.38 0.002 0.98
2 Δ Finger reactive hyperaemic index 0.51 0.64 0.006  
Vascular
 Δ Fasting calf vascular resistance (units) 1 Δ Insulin clearance (mL m2 min−1) −0.55 0.40 0.01 0.95
2 Δ Log high sensitivity CRP (mg/mL) 0.40 0.55 0.047  
 Δ Calf vascular resistance during OGTT (AUC0–120) (units) 1 Δ Fasting C-peptide (pmol/L) 0.63 0.48 <0.001 0.99
2 Δ M/I (mg kg FFM min−1 mU/L × 100) −0.47 0.69 0.008  
 Δ Finger reactive hyperaemic index 1 Δ Mean arterial pressure (mmHg) −0.57 0.33 0.02 0.69
 Δ Mean arterial pressure (mmHg) 1 Δ Log arterial norepinephrine (pg/mL) 0.53 0.28 0.03 0.59
 Δ MSNA (bursts/100hb) 1 Δ Cardiac baroreflex sensitivity (ms/mmHg) −0.71 0.36 0.005 0.92
2 Δ Body weight (kg) −0.51 0.61 0.03  
  1. Regression analyses were adjusted for age (years) and change in body weight (kg). β is the power of the test performed with α = 0.05