Reduction in peripheral vascular resistance predicts improvement in insulin clearance following weight loss

Table 3 Stepwise regression analyses of changes in key study parameters in the HCD group (n = 17)

Dependent variables	Step	Predictor variables	Std.coeff	r²	P	β
Insulin clearance
Δ Whole-body insulin clearance (mL m² min⁻¹)	1	Δ Calf vascular resistance (units)	−0.53	0.40	0.01	0.94
Δ Whole-body insulin clearance (mL m² min⁻¹)	2	Δ HDL-cholesterol (mmol/L)	0.40	0.55	0.05
Δ Fasting C-peptide to insulin ratio	1	Δ Glucose AUC_0-120 (mmol/L/min)	−0.63	0.38	0.002	0.98
Δ Fasting C-peptide to insulin ratio	2	Δ Finger reactive hyperaemic index	0.51	0.64	0.006
Vascular
Δ Fasting calf vascular resistance (units)	1	Δ Insulin clearance (mL m² min⁻¹)	−0.55	0.40	0.01	0.95
Δ Fasting calf vascular resistance (units)	2	Δ Log high sensitivity CRP (mg/mL)	0.40	0.55	0.047
Δ Calf vascular resistance during OGTT (AUC_0–120) (units)	1	Δ Fasting C-peptide (pmol/L)	0.63	0.48	<0.001	0.99
Δ Calf vascular resistance during OGTT (AUC_0–120) (units)	2	Δ M/I (mg kg FFM min⁻¹ mU/L × 100)	−0.47	0.69	0.008
Δ Finger reactive hyperaemic index	1	Δ Mean arterial pressure (mmHg)	−0.57	0.33	0.02	0.69
Δ Mean arterial pressure (mmHg)	1	Δ Log arterial norepinephrine (pg/mL)	0.53	0.28	0.03	0.59
Δ MSNA (bursts/100hb)	1	Δ Cardiac baroreflex sensitivity (ms/mmHg)	−0.71	0.36	0.005	0.92
Δ MSNA (bursts/100hb)	2	Δ Body weight (kg)	−0.51	0.61	0.03

Regression analyses were adjusted for age (years) and change in body weight (kg). β is the power of the test performed with α = 0.05

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