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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: Involvement of Rho-associated protein kinase (ROCK) and bone morphogenetic protein-binding endothelial cell precursor-derived regulator (BMPER) in high glucose-increased alkaline phosphatase expression and activity in human coronary artery smooth muscle cells

Fig. 1

Effects of rosuvastatin, mevalonate and GGPP on high glucose-increased ALP mRNA expression and activity. a ALP mRNA expression in aortas of STZ-induced type I diabetic mice. The values represent the mean ± SEM (n = 8–11). b ALP mRNA expression in HCASMCs cultured for 10 days. The values represent the mean ± SEM (n = 3–4). c The inhibitory effects of rosuvastatin on high glucose-induced ALP mRNA expression, and reversal by mevalonate and GGPP. HCASMCs were cultured with rosuvastatin, mevalonate, FPP and GGPP for 5 days in high glucose-containing media. The values represent the mean ± SEM (n = 6). d The inhibitory effects of rosuvastatin on high glucose-induced ALP activity, and reversal by mevalonate and GGPP. HCASMCs were cultured for 10 days. Representative images are shown. e Percentages of the ALP-positive area relative to the total surface area of HCASMCs. The data are presented as mean ± SEM (n = 5). Veh vehcle, RSV rosuvastatin, NG normal glucose, HG high glucose, M mannitol, Mev mevalonate. *P < 0.05; P < 0.01; ns not significant.

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