Table 1 Clinical characteristics of skin donors at DCCT baseline and mean AGE levels at time of DCCT biopsy
| Â | Primary | Secondary | P value |
|---|---|---|---|
NÂ =Â 216 | 123 | 93 | Â |
DCCT baseline | |||
 Female (%) | 53 % | 41 % |  |
 Age (years) | 27.1 (6.8) | 29.6 (6.5) | 0.009 |
 Duration (months) | 2.7 (1.4) | 8.6 (4) | <0.001 |
 HbA1c (%) (mmol/mol) | 9.1 (1.8) | 8.9 (1.5) |  |
 Mean blood glucose (mg/dl) | 230.4 (82.8) | 225.6 (71.5) |  |
 Triglycerides (mg/dl) | 72.4 (50.5) | 92.9 (51.6) | <0.001 |
 Cholesterol (mg/dl) | 178.3 (32.7) | 179.1 (36.5) | 0.006 |
 Retinopathy (%) |  |  |  |
  10/10: None | 100 | 0 |  |
  20/≤20: Microaneurysms only | 0 | 60 |  |
  30/≤30: Mild NPDR | 0 | 28 |  |
  45/≤45: Moderate NPDR | 0 | 11 |  |
 AER >40 mg/24 h | 1 | 10 | 0.003 |
 Confirmed clinical neuropathy (%) | 3 | 14 | 0.004 |
 sBP (mmHg) | 114.7 (11.9) | 119.4 (10.5) |  |
 dBP (mmHg) | 72.9 (8.5) | 75.1 (7.8) |  |
AGEs and solubility parameters | |||
 Acid soluble (%) | 0.5 (0.3) | 0.6 (0.4) |  |
 CEL (pmol/mg collagen) | 141.4 (104) | 152.5 (111.1) |  |
 CML (pmol/mg collagen) | 527.8 (140.4) | 548.1 (119.2) |  |
 Furosine (pmol/mg collagen) | 756.2 (239.9) | 786.2 (219.8) |  |
 G-H1 (pmol/mg collagen) | 66.8 (30.7) | 63.6 (38) |  |
 GSPNE (nmol/mg collagen) | 2.5 (0.6) | 2.6 (0.7) |  |
 MG-H1 (nmol/mg collagen) | 0.8 (0.4) | 0.8 (0.5) |  |
 Pentosidine (pmol/mg collagen) | 25.3 (6.2) | 26.6 (8.6) |  |
 Pepsin Soluble (%) | 6.8 (3.5) | 6.5 (3) |  |