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Table 2 Echocardiographic data at baseline

From: Inhibition of DPP-4 reduces acute mortality after myocardial infarction with restoration of autophagic response in type 2 diabetic rats

 

LETO

OLETF

Vehicle

Vildagliptin

Exenatide

Chloroquine

Vehicle

Vildagliptin

Exenatide

Vildagliptin + Chloroquine

HR (bpm)

384 ± 6

386 ± 7

385 ± 4

375 ± 6

312 ± 7*

316 ± 4*

315 ± 6*

324 ± 9*

LVEF (%)

69.4 ± 1.5

70.8 ± 1.3

68.4 ± 1.2

73.0 ± 1.3

65.4 ± 1.5

67.7 ± 0.7

68.5 ± 1.3

69.9 ± 1.3

FS (%)

35.0 ± 1.3

35.9 ± 1.0

34.0 ± 0.8

37.6 ± 1.5

32.1 ± 1.1

33.4 ± 0.5

34.4 ± 1.0

35.2 ± 1.1

IVST (mm)

1.72 ± 0.04

1.69 ± 0.02

1.76 ± 0.03

1.75 ± 0.04

1.81 ± 0.04

1.74 ± 0.03

1.73 ± 0.03

1.85 ± 0.02

PWT (mm)

1.66 ± 0.06

1.73 ± 0.05

1.64 ± 0.02

1.76 ± 0.06

1.85 ± 0.05

1.79 ± 0.04

1.83 ± 0.06

1.84 ± 0.03

LVEDD (mm)

7.04 ± 0.12

6.71 ± 0.19

7.11 ± 0.12

6.68 ± 0.12

8.05 ± 0.18*

7.69 ± 0.10*

7.88 ± 0.12*

7.65 ± 0.15*

LVESD (mm)

4.60 ± 0.15

4.34 ± 0.13

4.69 ± 0.09

4.16 ± 0.14

5.49 ± 0.17*

5.08 ± 0.10*

5.17 ± 0.12*

4.94 ± 0.07*

LVEDV (ml)

0.80 ± 0.04

0.75 ± 0.04

0.83 ± 0.04

0.69 ± 0.03

1.17 ± 0.07*

1.02 ± 0.04*

1.10 ± 0.04*

1.00 ± 0.06*

LVESV (ml)

0.26 ± 0.02

0.22 ± 0.01

0.26 ± 0.02

0.19 ± 0.02

0.41 ± 0.03*

0.37 ± 0.04*

0.35 ± 0.02*

0.30 ± 0.01*

  1. Values are mean ± SEM. N = 12–33.
  2. HR heart rate, bpm beats per minute, LVEF left ventricular ejection fraction, FS fractional shortening, IVST interventricular septal thickness, PWT posterior wall thickness, LVEDD left ventricular end-diastolic dimension, LVESD left ventricular end-systolic dimension, LVEDV left ventricular end-diastolic volume, LVESV left ventricular end-systolic volume.
  3. * P < 0.05 vs. LETO Vehicle.
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Cardiovascular Diabetology

ISSN: 1475-2840