Coronary microvascular function is independently associated with left ventricular filling pressure in patients with type 2 diabetes mellitus

Table 2 Laboratory and echocardiographic data

Variables	Patients n = 67	Controls n = 14	p
Laboratory data
FBS (mg/dl)	130.9 ± 40.1	97.0 ± 6.7	<0.0001
HbA1c (%)	7.8 ± 1.5	5.2 ± 0.2	<0.0001
IRI (µU/l)	8.8 ± 8.3	–
HOMA-R	2.9 ± 3.2	–
TG (mg/dl)	112.7 ± 50.2	120.0 ± 48.1	0.64
HDL-C (mg/dl)	46.1 ± 14.0	48.3 ± 7.7	0.43
LDL-C (mg/dl)	107.5 ± 27.2	114.0 ± 31.9	0.50
Creatinine (mg/dl)	0.79 ± 0.19	0.74 ± 0.14	0.31
eGFR ml/min./1.73 m²	78.1 ± 19.3	79.9 ± 13.3	0.69
Echocardiographic data
Left atrial diameter (mm)	36.2 ± 4.4	33.5 ± 4.3	0.044
RWT	0.43 ± 0.07	0.43 ± 0.06	0.72
LV mass index (g/m²)	84.7 ± 21.4	77.1 ± 14.7	0.13
LVEDV index (ml/m²)	55.8 ± 11.4	54.3 ± 8.9	0.61
LVESV index (ml/m²)	18.2 ± 5.0	18.5 ± 3.3	0.81
LVEF (%)	67.2 ± 5.1	65.6 ± 5.1	0.34
E/A	0.9 ± 0.3	0.9 ± 0.2	0.42
DT (msec)	194.8 ± 45.1	182.9 ± 42.0	0.37
Septal e′ (cm/sec)	7.0 ± 2.2	7.9 ± 1.7	0.11
E/e′	9.3 ± 2.7	7.6 ± 1.1	0.0004
MDV baseline (cm/sec)	15.3 ± 3.5	15.2 ± 3.9	0.89
MDV hyperemia (cm/sec)	50.6 ± 12.6	56.8 ± 11.6	0.088
CFR	3.3 ± 0.8	3.8 ± 0.7	0.036

Data are presented as mean ± SD.
FBS fasting blood sugar, HbA1c glycated hemoglobin, IRI immunoreactive insulin, HOMA-R homeostasis model assessment ratio, T-Cho total-cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, eGFR estimated glomerular filtration rate, RWT relative wall thickness, LVEDV/ESV left ventricular end-diastolic volume/end-systolic volume, LVEF left ventricular ejection fraction, DT deceleration time of mitral E wave, MDV mean diastolic coronary flow velocity, CFR coronary flow reserve.

ISSN: 1475-2840