Table 6 Genes significantly down-regulated in control MVT-treated vs. control vehicle-treated group on DNA microarray
Control MVT | Diabetes Vehicle | Diabetes MVT | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
vs. | vs. | vs. | ||||||||
Control Vehicle | Control Vehicle | Diabetes Vehicle | ||||||||
Gene function | Gene Name provided by RGD a | Acc. Number | Gene Symbol | Log2 (SD) | Corr. p | Fold change | Log2 (SD) | Fold Change | Log2 (SD) | Fold Change |
Stress response | APEX (apurinic/apyrimidinic) endonuclease) 2 | NM_001079892 | Apex2 | −1.18 (0.63) | 0.043 | −2.26 | −0.94 (0.56) | −1.92 | 0.09 (0.26) | 1.06 |
Receptors and ion channels | sodium leak channel, non-selective | NM_153630 | Nalcn | −0.85 (0.44) | 0.043 | −1.80 | −0.59 (0.36) | −1.50 | 0.16 (0.41) | 1.12 |
Signal transduction, regulation of transcription | triggering receptor expressed on myeloid cells 2 | NM_001106884 | Trem2 | −1.03 (0.40) | 0.021 | −2.05 | −0.21 (0.88) | −1.15 | −0.98 (0.94) | −1.98 |
Transport | hemoglobin, beta adult major chain | NM_198776 | Hbb-b1 | −2.23 (0.76) | 0.016 | −4.71 | −1.94 (0.75) | −3.83 | −0.40 (0.77) | −1.32 |
Transport | globin, alpha | NM_001013853 | LOC287167 | −1.80 (0.76) | 0.020 | −3.47 | −1.64 (0.72) | −3.12 | −0.23 (0.81) | −1.18 |
Others | EF-hand calcium binding domain 6 | XM_001077962 | Efcab6 | −1.66 (0.62) | 0.017 | −3.15 | 0.40 (0.99) | 1.32 | −1.36b (1.38) | −2.57 |