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Fig. 2 | Cardiovascular Diabetology

Fig. 2

From: Rivaroxaban, a factor Xa inhibitor, improves neovascularization in the ischemic hindlimb of streptozotocin-induced diabetic mice

Fig. 2

Effects of rivaroxaban on eNOS and VEGF production in ischemic tissues of mice. Impaired expression of eNOS, p-eNOS, and VEGF of ischemic tissues in diabetic control mice compared to non-diabetic control mice. Treatment with rivaroxaban in diabetic mice promoted eNOS, p-eNOS, and VEGF production of ischemic tissues compared to diabetic control mice. The expression of VEGF was enhanced in a dose-dependent effect of diabetic mice treated with rivaroxaban. Each bar graph shows the summarized data from six separate experiments by densitometry after normalization. Data are the mean ± SEM. (*P < 0.05 compared with non-diabetic control mice, # P < 0.05 compared with diabetic control mice; n = 6)

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Cardiovascular Diabetology

ISSN: 1475-2840