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Fig. 5 | Cardiovascular Diabetology

Fig. 5

From: Fibroblast growth factor 21 deletion aggravates diabetes-induced pathogenic changes in the aorta in type 1 diabetic mice

Fig. 5

FGF21 deficiency accelerated and aggravated diabetes-induced oxidative stress. At indicated time points after diabetes onset, oxidative stress was evaluated by immunohistochemical staining of 3-NT (a, b) and 4-HNE (c, d). Antioxidative response was also evaluated by immunohistochemical staining of transcription factor Nrf2 (e,f). Data are presented as means ± SD, n ≥ 5 for each group. * p < 0.05 vs WT Ctrl group; # p < 0.05 vs FGF21KO Ctrl group; & p < 0.05 vs WT DM group. Bar = 50 μm. Abbreviations are the same as the Fig. 1

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Cardiovascular Diabetology

ISSN: 1475-2840