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Table 2 Renal function analysis

From: Chronic NF-κB blockade improves renal angiotensin II type 1 receptor functions and reduces blood pressure in Zucker diabetic rats

Group

LZ Control

LZ PDTC

ZDF Control

ZDF PDTC

Kidney weight (g)

1.02 ± 0.03

1.01 ± 0.02

1.83 ± 0.04*

1.80 ± 0.03*

Water intake (ml/day)

17.3 ± 0.64

16.9 ± 0.84

22.3 ± 0.69*

21.8 ± 0.74*

Creatinine (mg/dl)

0.62 ± 0.05

0.63 ± 0.05

1.25 ± 0.13*

0.77 ± 0.04#

Urinary albumin (mg/24 h)

10.69 ± 0.97

10.36 ± 1.55

60.49 ± 4.93*

36.19 ± 3.23*#

Urine Volume (ml/day)

7.09 ± 0.48

6.83 ± 0.64

8.28 ± 0.50*

10.02 ± 0.90*#

Normalized urine volume (ml/day/kg · body wt)

24.74 ± 2.17

24.10 ± 2.44

19.42 ± 1.50*

23.95 ± 1.21#

UNaV (mmol/day)

224.5 ± 13.3

227.8 ± 20.4

264.4 ± 11.4*

298.9 ± 14.5*#

Normalized UnaV (μmol/day /kg · body wt)

782.8 ± 62.9

801.8 ± 74.5

596.3 ± 37.8*

730.1 ± 58.2#

GFR (ml/min)

1.01 ± 0.04

0.96 ± 0.05

0.75 ± 0.03*

0.88 ± 0.04#

  1. Effect of PDTC on renal function in LZ and ZDF rats. Data are expressed as mean ± SEM (n = 5/group). P < 0.05 was considered statistically significant. * P <0.05 vs. LZ control; # P < 0.05 vs. ZDF control