Fig. 5
Effect of PDTC on AT1 receptor function in LZ and ZDF rats. LZ or ZDF rats were treated with PDTC (150 mg · kg body wt-1 · day-1) or vehicle for 4 weeks. Adjusting for kidney weight, urine flow (a) and urinary sodium excretion (UNaV) (b) were recorded during the vehicle or candesartan (10 μg/kg body wt per min) infusion via the right supraenal artery of anesthetized rats. Values of three durg (drug 1, drug 2, and drug 3) collections were averaged and were shown. Results are shown as mean ± SEM (n = 6/group). * P < 0.05 vs respective basal; # P < 0.05 vs lean control within the same treatment; $ P < 0.05 vs obese control within the same treatment