Association of elevated apoA-I glycation and reduced HDL-associated paraoxonase1, 3 activity, and their interaction with angiographic severity of coronary artery disease in patients with type 2 diabetes mellitus

Table 4 Extent index and cumulative coronary stenosis score in relation to apoA-I glycation and HDL-associated PON1, 3 activities

			Extent index			Cumulative coronary stenosis score
			Adjusted R²	β ± SE	P value	Adjusted R²	β ± SE	P value
Model 1	A	Relative intensity of apoA-I glycation	0.589	0.407 ± 0.004	< 0.001	0.636	0.483 ± 0.022	< 0.001
	A	HDL-associated PON1 activity		−0.439 ± 0.000	< 0.001		−0.302 ± 0.002	< 0.001
	B	Relative intensity of apoA-I glycation	0.627	0.760 ± 0.007	< 0.001	0.645	0.666 ± 0.039	< 0.001
		HDL-associated PON1 activity		0.207 ± 0.001	0.179		0.033 ± 0.004	0.827
		*Interaction		−0.603 ± 0.000	< 0.001		−0.312 ± 0.001	0.019
Model 1	A	Relative intensity of apoA-I glycation	0.541	0.395 ± 0.005	< 0.001	0.634	0.448 ± 0.023	< 0.001
	A	HDL-associated PON3 activity		−0.383 ± 0.000	< 0.001		−0.320 ± 0.002	< 0.001
	B	Relative intensity of apoA-I glycation	0.558	0.623 ± 0.008	< 0.001	0.658	0.707 ± 0.037	< 0.001
		HDL-associated PON3 activity		0.116 ± 0.001	0.523		0.247 ± 0.06	0.124
		*Interaction		−0.441 ± 0.000	0.004		−0.500 ± 0.001	< 0.001

Values are regression coefficients (β) ± standard error (SE)
The relative intensity of apoA-I glycation in addition with HDL-associated PON1, 3 activity were included (Model 1A and Model 2A). The interactions between the relative intenstity of apoA-I glycation and HDL-associated PON1, 3 activities were further included (Model 1B andModel 2B). All models were adjusted for gender, age, body mass index, history of hypertension and dyslipidemia, smoking, glycatedhemoglobin A1c, estimated glomerular filtration rate, total/HDL cholesterol ratio, high-sentivity C-reactive protein and use of statins. apoA-I, apolipoprotein A-I; HDL, high-density lipoprotein; PON, paraoxonase
*Interaction denote the interaction between relative intenstity of apoA-I glycation and HDL-associated paraoxonase activities. Extent indexCumulative coronary stenosis scoreModel 1

ISSN: 1475-2840