Skip to main content

Table 2 a-d Hazard ratios for ischemic heart disease during follow up

From: Serum leptin levels are independently related to the incidence of ischemic heart disease in a prospective study of patients with type 2 diabetes

Variable

Hazard ratio

Lower CI

Higher CI

P value

Men

    

2a

    

Age (years)

.987

.882

1.106

.828

Diabetes duration (years)

1.034

.994

1.076

.098

Smoking (current, former, never)

1.883

1.126

3.151

.016

BMI (kg/m2)

.913

.822

1.014

.089

Systolic blood pressure (mmHg)

1.030

1.010

1.049

.003

HbA1c (mmol/mol)

.999

.973

1.027

.958

LDL/HDL-ratio

1.260

.810

1.961

.305

Serum leptin (log 10 of ng/ml)

12.895

3.162

52.589

<0.001

2b

    

Age (years)

.968

.861

1.089

.591

Diabetes duration (years)

1.034

.991

1.079

.127

Smoking (current, former, never)

1.570

.913

2.700

.103

BMI (kg/m2)

.946

.842

1.063

.349

Systolic blood pressure (mmHg)

1.024

1.003

1.046

.028

HbA1c (mmol/mol)

1.001

.971

1.032

.947

LDL/HDL-ratio

1.189

.737

1.919

.478

IMT (mm)

2.839

.721

11.180

.136

PWV (m/s)

.953

.800

1.134

.584

Serum leptin (log 10 of ng/ml)

9.219

2.088

40.705

.003

Women

    

2c

    

Age (years)

1.073

.861

1.337

.530

Diabetes duration (years)

1.060

.963

1.166

.231

Smoking (current, former, never)

1.190

.470

3.013

.713

BMI (kg/m2)

.995

.854

1.159

.949

Systolic blood pressure (mmHg)

.980

.932

1.030

.418

HbA1c (mmol/mol)

1.050

.992

1.110

.090

LDL/HDL-ratio

1.733

.789

3.804

.171

Leptin (log 10 of ng/ml)

19.9

1.205

327

.037

2d

    

Age (years)

1.118

.831

1.506

.461

Diabetes duration (years)

1.08

.958

1.219

.205

Smoking (current, former, never)

1.18

.365

3.815

.783

BMI (kg/m2)

.934

.739

1.181

.570

Systolic blood pressure (mmHg)

1.035

.967

1.107

.321

HbA1c (mmol/mol)

1.06

.990

1.143

.094

LDL/HDL-ratio

3.85

1.091

13.6

.036

IMT (mm)

57.913

.603

5563.346

.081

PWV (m/s)

.515

.262

1.013

.055

Leptin (log 10 of ng/ml)

26.8

.432

1662

.118

  1. Cox regression of ischemic heart disease incidence (Proportional Hazard Model) in relation to leptin levels and traditional risk factors, with (2b and 2d) or without (2a and 2c) addition of intima-media thickness of carotid arteries and carotid-femoral pulse wave velocity. Table 2a and b are data for the men, 2c and 2d show data for the women.
  2. Abbreviations: BMI, body mass index; HDL, high density lipoprotein; IMT, intima-media thickness of carotid arteries; LDL, low density lipoprotein; PWV, carotid-femoral pulse wave velocity.