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Table 2 a-d Hazard ratios for ischemic heart disease during follow up

From: Serum leptin levels are independently related to the incidence of ischemic heart disease in a prospective study of patients with type 2 diabetes

Variable Hazard ratio Lower CI Higher CI P value
Men     
2a     
Age (years) .987 .882 1.106 .828
Diabetes duration (years) 1.034 .994 1.076 .098
Smoking (current, former, never) 1.883 1.126 3.151 .016
BMI (kg/m2) .913 .822 1.014 .089
Systolic blood pressure (mmHg) 1.030 1.010 1.049 .003
HbA1c (mmol/mol) .999 .973 1.027 .958
LDL/HDL-ratio 1.260 .810 1.961 .305
Serum leptin (log 10 of ng/ml) 12.895 3.162 52.589 <0.001
2b     
Age (years) .968 .861 1.089 .591
Diabetes duration (years) 1.034 .991 1.079 .127
Smoking (current, former, never) 1.570 .913 2.700 .103
BMI (kg/m2) .946 .842 1.063 .349
Systolic blood pressure (mmHg) 1.024 1.003 1.046 .028
HbA1c (mmol/mol) 1.001 .971 1.032 .947
LDL/HDL-ratio 1.189 .737 1.919 .478
IMT (mm) 2.839 .721 11.180 .136
PWV (m/s) .953 .800 1.134 .584
Serum leptin (log 10 of ng/ml) 9.219 2.088 40.705 .003
Women     
2c     
Age (years) 1.073 .861 1.337 .530
Diabetes duration (years) 1.060 .963 1.166 .231
Smoking (current, former, never) 1.190 .470 3.013 .713
BMI (kg/m2) .995 .854 1.159 .949
Systolic blood pressure (mmHg) .980 .932 1.030 .418
HbA1c (mmol/mol) 1.050 .992 1.110 .090
LDL/HDL-ratio 1.733 .789 3.804 .171
Leptin (log 10 of ng/ml) 19.9 1.205 327 .037
2d     
Age (years) 1.118 .831 1.506 .461
Diabetes duration (years) 1.08 .958 1.219 .205
Smoking (current, former, never) 1.18 .365 3.815 .783
BMI (kg/m2) .934 .739 1.181 .570
Systolic blood pressure (mmHg) 1.035 .967 1.107 .321
HbA1c (mmol/mol) 1.06 .990 1.143 .094
LDL/HDL-ratio 3.85 1.091 13.6 .036
IMT (mm) 57.913 .603 5563.346 .081
PWV (m/s) .515 .262 1.013 .055
Leptin (log 10 of ng/ml) 26.8 .432 1662 .118
  1. Cox regression of ischemic heart disease incidence (Proportional Hazard Model) in relation to leptin levels and traditional risk factors, with (2b and 2d) or without (2a and 2c) addition of intima-media thickness of carotid arteries and carotid-femoral pulse wave velocity. Table 2a and b are data for the men, 2c and 2d show data for the women.
  2. Abbreviations: BMI, body mass index; HDL, high density lipoprotein; IMT, intima-media thickness of carotid arteries; LDL, low density lipoprotein; PWV, carotid-femoral pulse wave velocity.