Low fasting glucose is associated with enhanced thrombin generation and unfavorable fibrin clot properties in type 2 diabetic patients with high cardiovascular risk

Table 4 The multiple regression analysis with clot permeability and lysis time as the dependent variables

Dependent variable	Independent variables	P -value	Coefficient	95.0% CI
Clot permeability	PF4	<0.001	−0.46	−0.57	−0.33
R = 0.62, R² = 0.38,	Fibrinogen	<0.001	−0.27	−0.41	−0.12
F(6, 156) = 13.8, p < 0.0001	HbA1c	0.002	−0.19	−0.33	−0.04
	DM duration	0.005	−0.22	−0.36	−0.07
	Glucose	0.002	0.61	0.50	0.70
	Glucose squared	0.008	−0.56	−0.66	−0.44
Lysis time	PF4	<0.001	0.41	0.27	0.53
R = 0.58, R² = 0.34,	Fibrinogen	<0.001	0.22	0.07	0.36
F(6, 156) = 11.4, P < 0.0001	DM duration	0.002	0.25	0.10	0.39
	HbA1c	0.002	0.20	0.05	0.34
	Glucose	0.008	−0.47	−0.58	−0.32
	Glucose squared	0.045	0.30	0.15	0.43
Peak thrombin generation	Glucose	<0.001	−0.97	−0.98	−0.96
R = 0.51, R² = 0.26,	Glucose squared	0.014	0.83	0.77	0.87
F(6, 155) = 8.8, P < 0.0001	Fibrinogen	0.002	0.22	0.07	0.36
	DM duration	0.005	0.21	0.06	0.35
	HbA1c	0.015	0.21	0.06	0.36
	Age	0.03	−0.15	−0.30	0

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