Table 3 Mean (SD) for changes in CFR and secondary outcomes between treatment allocations
Variable | Changes during no treatment (SD) | Changes during liraglutide (SD) | Difference between changes (95% confidence interval) | p-value* |
|---|---|---|---|---|
CFR | 0.02 (0.32) | 0.18 (0.38) | 0.16 [-0.08; 0.40] | 0.18 |
RHI | 0.03 (0.30) | 0.12 (0.51) | 0.09 [-0.17; 0.36] | 0.49 |
AI | -1.4 (8.9) | -1.2 (9.6) | 0.20 [-5.7; 6.1] | 0.95 |
HbA1c (mmol/mol) | 0.9 (6.3) | -9.2 (5.1) | -10.1 [-13.9; -6.4] | 0.01 |
Weight (Kg) | -0.1 (2.5) | - 2.0 (2.8) | -1.9 [-3.6; -0.2] | 0.03 |
Waist circumference (cm) | -1 (4) | -1 (2) | 1 [-2; 2] | 0.96 |
Systolic BP (mmHg) | 5 (12) | -5 (9) | -10 [-17; -3] | 0.01 |
Diastolic BP (mmHg) | 1 (7) | -1 (8) | -2 [-7; 3] | 0.35 |
Heart rate (bpm) | 4 (10) | 4 (9) | 0.05 [-6; 6] | 0.97 |
Fasting glucose (mmol/L) | 0.52 (1.85) | -1.61 (1.54) | -2.13 [-3.24; -1.03] | <0.001 |
Insulin (μU/ml) | -3 (39) | -10 (45) | -6 [-34; 21] | 0.65 |
C-peptide (pmol/L) | 21 (280) | 52 (279) | 31 [-150; 212] | 0.73 |
HOMA index | 0.1 (3.6) | -1.5 (3.2) | -1.6 [-3.7; 0.5] | 0.13 |