Non–IS/TIA | IS/TIA | eGFR category | |||||
---|---|---|---|---|---|---|---|
n = 54,161 | n = 3785 | Overall | 15–29 mL/min | 30–44 mL/min | 45–59 mL/min | ≥60 mL/min | |
Number (%) | Number (%) | HR a (95% CI) | HR b (95% CI) | HR b (95% CI) | HR b (95% CI) | HR b (95% CI) | |
Sex | |||||||
Men | 30,055 (55.5) | 2062 (54.5) | 1 (−) | 1 (−) | 1 (−) | 1 (−) | 1 (−) |
Women | 24,106 (44.5) | 1723 (45.5) | 0.95 (0.89–1.02) | 1.52 (0.94–2.46) | 1.07 (0.85–1.33) | 0.91 (0.80–1.04) | 0.93 (0.86–1.02) |
Age at start date (years) | |||||||
20–49 | 5614 (10.4) | 109 (2.9) | 1 (−) | – | – | 1 (−) | 1 (−) |
50–74 | 35,722 (66.0) | 2350 (62.1) | 2.83 (2.32–3.43) | 0.82 (0.53–1.25) | 0.74 (0.60–0.92) | 1.54 (0.80–2.99) | 2.76 (2.25–3.39) |
≥75 | 12,825 (23.7) | 1326 (35.0) | 5.33 (4.35–6.54) | 1 (−) | 1 (−) | 2.69 (1.38–5.24) | 5.95 (4.77–7.42) |
Duration of diabetes (years) | |||||||
<5 | 24,591 (45.4) | 1458 (38.5) | 1 (−) | 1 (−) | 1 (−) | 1 (−) | 1 (−) |
5–9 | 15,945 (29.4) | 1178 (31.1) | 1.12 (1.04–1.21) | 0.99 (0.58–1.69) | 1.10 (0.85–1.42) | 1.12 (0.96–1.30) | 1.12 (1.01–1.23) |
10–14 | 7874 (14.5) | 629 (16.6) | 1.16 (1.06–1.28) | 0.73 (0.37–1.43) | 1.05 (0.78–1.42) | 1.14 (0.95–1.37) | 1.20 (1.06–1.36) |
≥15 | 5751 (10.6) | 520 (13.7) | 1.27 (1.15–1.41) | 1.26 (0.72–2.22) | 1.35 (1.01–1.82) | 1.15 (0.94–1.41) | 1.29 (1.13–1.48) |
BMI (kg/m2) | |||||||
15–19 | 851 (1.6) | 64 (1.7) | 1.18 (0.91–1.52) | 1.26 (0.29–5.55) | 1.65 (0.82–3.34) | 1.44 (0.89–2.33) | 0.98 (0.69–1.39) |
20–24 | 8894 (16.4) | 652 (17.2) | 1 (−) | 1 (−) | 1 (−) | 1 (−) | 1 (−) |
25–29 | 19,554 (36.1) | 1457 (38.5) | 1.01 (0.92–1.10) | 0.71 (0.38–1.32) | 1.09 (0.80–1.47) | 1.13 (0.93–1.36) | 0.97 (0.86–1.09) |
≥30 | 21,625 (39.9) | 1334 (35.2) | 0.93 (0.84–1.02) | 0.70 (0.39–1.27) | 1.03 (0.75–1.40) | 1.10 (0.91–1.34) | 0.86 (0.76–0.98) |
Unknown | 3237 (6.0) | 278 (7.3) | 1.24 (1.07–1.43) | 1.31 (0.63–2.69) | 1.45 (0.96–2.18) | 1.40 (1.06–1.85) | 1.11 (0.91–1.36) |
Smoking status | |||||||
Non–smoker | 28,212 (52.1) | 1963 (51.9) | 1 (−) | 1 (−) | 1 (−) | 1 (−) | 1 (−) |
Current | 9463 (17.5) | 665 (17.6) | 1.19 (1.09–1.30) | 0.74 (0.33–1.65) | 1.20 (0.88–1.64) | 1.13 (0.94–1.37) | 1.24 (1.11–1.38) |
Former | 14,046 (25.9) | 965 (25.5) | 1.03 (0.95–1.11) | 1.09 (0.66–1.81) | 0.80 (0.62–1.04) | 0.91 (0.78–1.07) | 1.12 (1.01–1.24) |
Unknown | 2440 (4.5) | 192 (5.1) | 1.06 (0.91–1.24) | 1.66 (0.81–3.40) | 1.17 (0.75–1.83) | 1.14 (0.85–1.54) | 0.97 (0.79–1.20) |
Number of medications | |||||||
0–1 | 14,249 (26.3) | 758 (20.0) | 1 (−) | 1 (−) | 1 (−) | 1 (−) | 1 (−) |
2–4 | 19,205 (35.5) | 1253 (33.1) | 1.14 (1.04–1.25) | 1.48 (0.68–3.23) | 1.02 (0.72–1.46) | 1.17 (0.97–1.41) | 1.12 (1.00–1.25) |
5–9 | 17,266 (31.9) | 1414 (37.4) | 1.28 (1.16–1.40) | 1.06 (0.51–2.20) | 1.11 (0.80–1.54) | 1.16 (0.97–1.40) | 1.34 (1.20–1.51) |
≥10 | 3441 (6.4) | 360 (9.5) | 1.65 (1.44–1.89) | 1.15 (0.50–2.62) | 1.42 (0.96–2.09) | 1.77 (1.38–2.27) | 1.64 (1.36–1.97) |
HbA1c (%) | |||||||
<7.00 | 18,214 (33.6) | 1168 (30.9) | 1 (−) | 1 (−) | 1 (−) | 1 (−) | |
7.00–7.99 | 12,029 (22.2) | 794 (21.0) | 1.02 (0.93–1.12) | 1.56 (0.89–2.74) | 0.95 (0.72–1.25) | 0.96 (0.81–1.14) | 1.04 (0.92–1.17) |
8.00–8.99 | 6730 (12.4) | 491 (13.0) | 1.12 (1.00–1.24) | 0.72 (0.31–1.63) | 1.17 (0.83–1.63) | 0.93 (0.75–1.15) | 1.22 (1.06–1.39) |
9.00–9.99 | 4297 (7.9) | 337 (8.9) | 1.30 (1.15–1.47) | 1.15 (0.46–2.87) | 1.24 (0.84–1.83) | 1.32 (1.03–1.68) | 1.33 (1.14–1.56) |
≥10.00 | 4474 (8.3) | 324 (8.6) | 1.33 (1.17–1.51) | 1.17 (0.53–2.58) | 0.72 (0.42–1.24) | 1.13 (0.86–1.48) | 1.52 (1.31–1.77) |
Missing | 8417 (15.5) | 671 (17.7) | 1.20 (1.09–1.33) | 1.36 (0.77–2.41) | 0.96 (0.72–1.30) | 1.15 (0.96–1.39) | 1.28 (1.13–1.44) |
Comorbiditiesc | |||||||
Hypertension | 30,384 (56.1) | 2368 (62.6) | 1.07 (1.00–1.14) | 0.81 (0.52–1.28) | 1.06 (0.84–1.33) | 1.09 (0.95–1.25) | 1.07 (0.98–1.16) |
Hyperlipidemia | 3648 (6.7) | 350 (9.2) | 1.23 (1.09–1.39) | 1.79 (1.15–2.79) | 1.42 (1.10–1.82) | 1.21 (0.98–1.48) | 1.17 (0.96–1.43) |
History of MI | 5134 (9.5) | 447 (11.8) | 0.97 (0.87–1.08) | 1.12 (0.65–1.91) | 0.77 (0.57–1.03) | 1.06 (0.87–1.30) | 0.98 (0.84–1.14) |
History of IS/TIA | 4710 (8.7) | 965 (25.5) | 3.26 (3.02–3.52) | 1.97 (1.25–3.12) | 2.89 (2.33–3.59) | 3.09 (2.68–3.57) | 3.57 (3.22–3.95) |
History of IHDd | 9308 (17.2) | 890 (23.5) | 1.16 (1.07–1.27) | 0.81 (0.50–1.31) | 1.45 (1.15–1.83) | 1.06 (0.91–1.24) | 1.18 (1.05–1.32) |
COPD | 2458 (4.5) | 193 (5.1) | 1.04 (0.89–1.20) | 1.15 (0.56–2.39) | 0.79 (0.50–1.26) | 1.07 (0.81–1.41) | 1.03 (0.85–1.26) |
Thyroid disease | 4571 (8.4) | 361 (9.5) | 1.01 (0.90–1.13) | 0.72 (0.40–1.31) | 0.97 (0.72–1.29) | 0.99 (0.81–1.21) | 1.07 (0.91–1.25) |
DVT | 3139 (5.8) | 290 (7.7) | 1.15 (1.02–1.29) | 0.67 (0.32–1.39) | 1.50 (1.09–2.07) | 1.30 (1.05–1.60) | 1.02 (0.85–1.21) |
PAD | 3330 (6.1) | 365 (9.6) | 1.22 (1.09–1.36) | 0.96 (0.54–1.68) | 1.35 (1.02–1.77) | 1.36 (1.11–1.67) | 1.15 (0.98–1.35) |
Anemia | 3298 (6.1) | 263 (6.9) | 1.04 (0.92–1.19) | 0.82 (0.47–1.44) | 1.01 (0.74–1.38) | 1.05 (0.83–1.33) | 1.08 (0.90–1.30) |
Atrial fibrillation | 3273 (6.0) | 221 (5.8) | 0.95 (0.83–1.09) | 0.61 (0.22–1.68) | 0.82 (0.52–1.29) | 0.85 (0.63–1.13) | 1.05 (0.89–1.24) |
Heart failure | 3755 (6.9) | 256 (6.8) | 0.97 (0.86–1.11) | 0.76 (0.30–1.91) | 1.08 (0.74–1.57) | 1.06 (0.83–1.34) | 0.95 (0.80–1.12) |
Gout | 3299 (6.1) | 300 (7.9) | 1.17 (1.04–1.32) | 0.86 (0.47–1.59) | 1.15 (0.84–1.59) | 1.34 (1.07–1.66) | 1.11 (0.94–1.32) |
Cancer | 4845 (8.9) | 450 (11.9) | 1.30 (1.18–1.44) | 0.84 (0.42–1.69) | 1.33 (1.01–1.75) | 1.09 (0.90–1.33) | 1.43 (1.25–1.63) |