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Table 2 Associations between lnMMP-1, −2, −3, −9, −10 and TIMP-1 and the LGI and ED scores

From: Plasma levels of matrix metalloproteinase-2, -3, -10, and tissue inhibitor of metalloproteinase-1 are associated with vascular complications in patients with type 1 diabetes: the EURODIAB Prospective Complications Study

  Inflammation (z-score) Endothelial dysfunction (z-score)
  Model β 95% CI p-value β 95% CI p-value
MMP-1 1 0.07 −0.02;0.15 0.112 0.00 −0.09;0.09 0.998
2 0.08 0.00;0.16 0.047 0.00 −0.09;0.08 0.987
3 0.08 −0.00;0.15 0.062 −0.01 −0.09;0.08 0.834
MMP-2 1 0.10 0.01;0.18 0.032 0.19 0.10;0.27 <0.001
2 0.03 −0.06;0.12 0.526 0.14 0.04;0.23 0.004
3 0.00 −0.08;0.09 0.950 0.13 0.04;0.22 0.006
MMP-3 1 0.26 0.16;0.36 <0.001 0.08 −0.03;0.19 0.137
2 0.19 0.09;0.30 0.001 −0.02 −0.14;0.10 0.715
3 0.17 0.06;0.28 0.003 −0.04 −0.16;0.08 0.474
MMP-9 1 0.16 0.08;0.25 <0.001 −0.02 −0.11;0.06 0.592
2 0.17 0.09;0.24 <0.001 −0.02 −0.10;0.07 0.718
3 0.16 0.08;0.24 <0.001 −0.02 −0.10;0.06 0.577
MMP-10 1 0.24 0.16;0.32 <0.001 0.13 0.04;0.21 0.003
2 0.22 0.14;0.30 <0.001 0.11 0.02;0.20 0.019
3 0.21 0.13;0.30 <0.001 0.10 0.01;0.19 0.029
TIMP-1 1 0.34 0.27;0.43 <0.001 0.25 0.17;0.33 <0.001
2 0.29 0.21;0.38 <0.001 0.21 0.12;0.30 <0.001
3 0.28 0.20;0.37 <0.001 0.20 0.11;0.29 <0.001
  1. β, standardized regression coefficient: indicates increase in the low-grade inflammation and endothelial dysfunction score (in SDs) per 1 SD increase in lnMMP-1, −2, −3, −9, −10 or TIMP-1. CI: confidence interval. MMP: matrix metalloproteinase.
  2. Model 1: adjusted for age, sex, duration of diabetes and HbA1c.
  3. Model 2: model 1 + BMI, triglycerides, LDL, HDL, systolic blood pressure, eGFR, smoking and antihypertensive medication.
  4. Model 3: model 2 + CVD, albuminuria and retinopathy.