Figure 1
![Figure 1](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12933-015-0192-5/MediaObjects/12933_2015_192_Fig1_HTML.gif)
Suggested chronological events in type II diabetes. Inflammatory markers that are known to be dysregulated in diabetes (1); and to cause oxidative stress (2); resulting in chronic (systemic) inflammation (3); that have been associated with hypercoagulability (4). Dysregulations, as indicated by 1 to 4 have all been found in diabetes type II (5); 1 to 5 are early indicators of vascular dysfunction (6). Literature references are given in Table 1.