Association of obesity and long-term mortality in patients with acute myocardial infarction with and without diabetes mellitus: results from the MONICA/KORA myocardial infarction registry

Table 3 Hazard ratios for mortality associated with elevated body mass index in patients with and without diabetes stratified by prescribed medications before and after myocardial infarction

		No diabetes (n=2864)		Diabetes (n=1190)
		HR [95% CI]	p-value	HR [95% CI]	p-value
Statins prior AMI	Normal weight	1.0		1.0
	Overweight	0.81 [0.44-1.52]^a	0.5179	0.51 [0.29-0.89]^b	0.0180
	Obesity	0.59 [0.26-1.35]^a	0.2115	0.82 [0.46-1.47]^b	0.5102
No statins prior AMI	Normal weight	1.0		1.0
	Overweight	0.71 [0.55-0.92]^a	0.0082	1.04 [0.71-1.52]^b	0.8456
	Obesity	0.66 [0.47-0.92]^a	0.0131	1.09 [0.73-1.64]^b	0.6697
Four medications at discharge^c	Normal weight	1.0		1.0
	Overweight	0.76 [0.56-1.03]^e	0.0805	0.52 [0.34-0.80]^f	0.0027
	Obesity	0.56 [0.37-0.86]^e	0.0072	0.82 [0.54-1.26]^f	0.3745
Less than four medications at discharge^d	Normal weight	1.0		1.0
	Overweight	0.67 [0.47-0.95]^e	0.0260	1.21 [0.71-1.89]^f	0.4095
	Obesity	0.70 [0.44-1.11]^e	0.1320	1.03 [0.62-1.73]^f	0.9062

HR=Hazard Ratio, CI=Confidence Interval, AMI=Acute Myocardial Infarction, BMI=Body Mass Index.
^aParsimonious model adjusted for sex, age, stroke, smoking, re-infarction, any reperfusion treatment (coronary artery bypass surgery, percutaneous coronary intervention (PCI) or thrombolysis), beta-blockers (medication prior AMI), all four medications at discharge (antiplatelet agents, beta-blockers, Angiotensin-converting enzyme inhibitors (ACEIs)/Angiotensin receptor blockers (ARBs), statins), left ventricular ejection fraction (<30% versus ≥ 30%).
^bParsimonious model adjusted for sex, age, hyperlipidemia, re-infarction, any reperfusion treatment, all four medications at discharge.
^cEvidence-based medications (EBMs): Antiplatelet agents, beta-blockers, ACEIs/ARBs, statins.
^dEither antiplatelet agents, beta-blockers, ACEIs/ARBs, statins or a combination of two or three of these medications.
^eParsimonious model adjusted for sex, age, stroke, smoking, re-infarction, any reperfusion treatment, beta-blockers (medication prior AMI), left ventricular ejection fraction (<30% versus ≥ 30%).
^fParsimonious model adjusted for sex, age, hyperlipidemia, re-infarction, any reperfusion treatment, statins (medication prior AMI).

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