Effects of exenatide on postprandial vascular endothelial dysfunction in type 2 diabetes mellitus

Table 2 Change in glucose and lipid metabolism after meal loading tests, preceded by placebo (baseline) or exenatide injection

	Baseline	Exenatide	P value
Glucose metabolism variables
AUC of plasma glucose [(mg/dL) · hr]	855.4 ± 45.3	442.3 ± 26.4	0.001
CV of plasma glucose	0.19 ± 0.02	0.20 ± 0.01	0.776
AUC of IRI [(μIU/mL) · hr]	96.7 ± 18.5	84.6 ± 28.9	0.211
CV of IRI	0.49 ± 0.04	0.53 ± 0.05	0.427
Lipid metabolism variables
AUC of TG [(mg/dL) · hr]	616.8 ± 68.7	475.5 ± 45.7	0.001
CV of TG	0.14 ± 0.02	0.06 ± 0.02	0.001
AUC of HDL-C [(mg/dL) · hr]	171.8 ± 12.2	177.2 ± 13.4	0.064
CV of HDL-C	0.03 ± 0.003	0.03 ± 0.003	0.730
AUC of LDL-C [(mg/dL) · hr]	419.0 ± 35.1	436.3 ± 32.8	0.221
CV of LDL-C	0.03 ± 0.003	0.03 ± 0.003	0.875

Data are mean ± SEM.
Abbreviations: AUC area under the curve, CV coefficient of variation, IRI immunoreactive insulin, TG triglycerides, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol.

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