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Figure 5 | Cardiovascular Diabetology

Figure 5

From: Liraglutide attenuates high glucose-induced abnormal cell migration, proliferation, and apoptosis of vascular smooth muscle cells by activating the GLP-1 receptor, and inhibiting ERK1/2 and PI3K/Akt signaling pathways

Figure 5

Liraglutide (LIRA) suppressed the high glucose (HG)-induced activation of PI3K/Akt and ERK1/2 signaling pathways by activating the GLP-1 receptor. (A) Protein expression of phosphorylated Akt in vascular smooth muscle cells (VSMCs). (B) Protein expression of phosphorylated ERK1/2 in VSMCs. Data from three independent experiments are expressed as mean ± standard deviation; * p < 0.01 vs. control; # p < 0.01 vs. HG; ** p < 0.05, † p < 0.01 vs. HG + LIRA.

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Cardiovascular Diabetology

ISSN: 1475-2840