AUC
1–4h
for postprandial insulin, μIU · h/ml
| | | |
Baseline
|
66.4 (63.5)*
|
58.9 (55.6)
|
65.3 (46.2)
|
Relative change from baseline at day 1
|
1.2 (1.1, 1.3)
|
1.0 (0.9, 1.1)
|
1.0 (0.9, 1.0)
|
Difference vs placebo (95% CI)
| |
0.8 (0.7, 0.9)
|
0.8 (0.7, 0.9)
|
p-value
| |
<0.001
|
<0.001
|
Relative change from baseline at day 28
|
1.0 (0.9, 1.1)
|
0.9 (0.8, 0.9)
|
0.8 (0.7, 0.9)
|
Difference vs placebo (95% CI)
| |
0.9 (0.8, 1.0)
|
0.8 (0.7, 0.9)
|
p-value
| |
0.074
|
0.002
|
AUC
10–13h
for postprandial insulin, μIU · h/ml
| | | |
Baseline
|
73.8 (56.6)†
|
60.7 (60.5)
|
70.0 (53.7)
|
Relative change from baseline at day 1
|
1.1 (1.0, 1.2)
|
0.9 (0.8, 1.0)
|
0.9 (0.8, 0.9)
|
Difference vs placebo (95% CI)
| |
0.8 (0.8, 0.9)
|
0.8 (0.7, 0.9)
|
p-value
| |
0.002
|
<0.001
|
Relative change from baseline at day 28
|
1.0 (0.9, 1.0)
|
0.8 (0.8, 0.9)
|
0.8 (0.7, 0.9)
|
Difference vs placebo (95% CI)
| |
0.9 (0.8, 1.0)
|
0.8 (0.7, 0.9)
|
p-value
| |
0.011
|
0.001
|