Effect of empagliflozin monotherapy on postprandial glucose and 24-hour glucose variability in Japanese patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled, 4-week study

Table 2 Changes in postprandial insulin after breakfast and dinner at day 1 and day 28

	Placebo (n = 20)	Empagliflozin 10 mg (n = 20)	Empagliflozin 25 mg (n = 19)
AUC _1–4h for postprandial insulin, μIU · h/ml
Baseline	66.4 (63.5)*	58.9 (55.6)	65.3 (46.2)
Relative change from baseline at day 1	1.2 (1.1, 1.3)	1.0 (0.9, 1.1)	1.0 (0.9, 1.0)
Difference vs placebo (95% CI)		0.8 (0.7, 0.9)	0.8 (0.7, 0.9)
p-value		<0.001	<0.001
Relative change from baseline at day 28	1.0 (0.9, 1.1)	0.9 (0.8, 0.9)	0.8 (0.7, 0.9)
Difference vs placebo (95% CI)		0.9 (0.8, 1.0)	0.8 (0.7, 0.9)
p-value		0.074	0.002
AUC _10–13h for postprandial insulin, μIU · h/ml
Baseline	73.8 (56.6)†	60.7 (60.5)	70.0 (53.7)
Relative change from baseline at day 1	1.1 (1.0, 1.2)	0.9 (0.8, 1.0)	0.9 (0.8, 0.9)
Difference vs placebo (95% CI)		0.8 (0.8, 0.9)	0.8 (0.7, 0.9)
p-value		0.002	<0.001
Relative change from baseline at day 28	1.0 (0.9, 1.0)	0.8 (0.8, 0.9)	0.8 (0.7, 0.9)
Difference vs placebo (95% CI)		0.9 (0.8, 1.0)	0.8 (0.7, 0.9)
p-value		0.011	0.001

Log-transformed data. Baseline data are gMean (% gCV), change from baseline data are adjusted gMean ratio (95% CI) based on analysis of covariance (ANCOVA) in the full analysis set. *63.8 (65.5) for day 1 analysis (n = 21). ^†72.8 (55.5) for day 1 analysis (n = 21).

ISSN: 1475-2840