Table 2 Changes in postprandial insulin after breakfast and dinner at day 1 and day 28
|  | Placebo (n = 20) | Empagliflozin 10 mg (n = 20) | Empagliflozin 25 mg (n = 19) |
|---|---|---|---|
AUC 1–4h for postprandial insulin, μIU · h/ml |  |  |  |
Baseline | 66.4 (63.5)* | 58.9 (55.6) | 65.3 (46.2) |
Relative change from baseline at day 1 | 1.2 (1.1, 1.3) | 1.0 (0.9, 1.1) | 1.0 (0.9, 1.0) |
 Difference vs placebo (95% CI) |  | 0.8 (0.7, 0.9) | 0.8 (0.7, 0.9) |
 p-value |  | <0.001 | <0.001 |
Relative change from baseline at day 28 | 1.0 (0.9, 1.1) | 0.9 (0.8, 0.9) | 0.8 (0.7, 0.9) |
 Difference vs placebo (95% CI) |  | 0.9 (0.8, 1.0) | 0.8 (0.7, 0.9) |
 p-value |  | 0.074 | 0.002 |
AUC 10–13h for postprandial insulin, μIU · h/ml |  |  |  |
Baseline | 73.8 (56.6)†| 60.7 (60.5) | 70.0 (53.7) |
Relative change from baseline at day 1 | 1.1 (1.0, 1.2) | 0.9 (0.8, 1.0) | 0.9 (0.8, 0.9) |
 Difference vs placebo (95% CI) |  | 0.8 (0.8, 0.9) | 0.8 (0.7, 0.9) |
 p-value |  | 0.002 | <0.001 |
Relative change from baseline at day 28 | 1.0 (0.9, 1.0) | 0.8 (0.8, 0.9) | 0.8 (0.7, 0.9) |
 Difference vs placebo (95% CI) |  | 0.9 (0.8, 1.0) | 0.8 (0.7, 0.9) |
 p-value |  | 0.011 | 0.001 |