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Table 2 Baseline characteristics, stratified by tertiles of (log)SFRP4

From: Association of secreted frizzled-related protein 4 (SFRP4) with type 2 diabetes in patients with stable coronary artery disease

(log) SFRP4 Tertiles
  1 2 3  
(log)SFRP4 range <0.99 0.99 - 1.11 >1.11 p-Value
Group size 33.3 (168) 33.3 (168) 33.3 (168)  
Age (years) 65.2 ± 0.7 65.8 ± 0.8 68.2 ± 0.8 0.017
Male 86.3 (145) 85.7 (144) 78.0 (131) 0.068
Medical history     
Previous myocardial infarction 35.7 (60) 44.6 (75) 51.8 (87) 0.014
PCI 57.1 (96) 66.7 (112) 76.8 (129) 0.001
Bypass operation 7.1 (12) 14.3 (24) 16.1 (27) 0.03
Previous stroke or TIA 6.0 (10) 12.5 (21) 13.1 (22) 0.065
Peripheral artery disease 6.5 (11) 10.1 (17) 10.7 (18) 0.37
Clinical characteristics     
Smoking 21.4 (36) 20.8 (35) 14.3 (24) 0.18
Alcohol regularly 27.4 (46) 25.0 (42) 19.0 (32) 0.18
Positive family history 31.5 (53) 29.2 (49) 32.1 (54) 0.79
Arterial hypertension 88.7 (149) 94.0 (158) 95.2 (160) 0.095
Systolic BP (mmHg) 124.3 ± 1.2 127.0 ± 1.2 128.2 ± 1.3 0.067
Diastolic BP (mmHg) 74.0 ± 0.7 74.9 ± 0.7 74.8 ± 0.8 0.62
BMI (kg/m2) 27.9 ± 0.3 29.4 ± 0.3 29.3 ± 0.4 0.002
Waist circumference (cm) 100.9 ± 0.8 104.9 ± 0.9 104.9 ± 0.9 0.001
Waist-to-hip-ratio 1.00 ± 0.0 1.00 ± 0.0 1.01 ± 0.0 0.36
Metabolic characterization     
Normal glucose tolerance 32.1 (54) 20.2 (34) 20.8 (35) 0.017
Impaired glucose tolerance 29.8 (50) 28.6 (48) 26.8 (45) 0.84
Diabetes mellitus 38.1 (64) 51.2 (86) 52.4 (88) 0.014
Metabolic syndrome 50.6 (85) 72.0 (121) 72.0 (121) <0.0001
Fasting glucose (mg/dl) 118.6 ± 2.5 119.5 ± 2.3 125.0 ± 2.6 0.15
Fasting insulin (μIU/ml) 8.73 ± 0.6 11.41 ± 0.9 12.69 ± 1.1 0.007
HOMA index 2.70 ± 0.24 3.64 ± 0.36 4.33 ± 0.55 0.018
HbA1c (%)* 6.05 ± 0.1 6.09 ± 0.1 6.40 ± 0.1 0.011
Total cholesterol (mg/dl) 175.0 ± 2.8 171.2 ± 3.2 170.9 ± 3.0 0.55
HDL cholesterol (mg/dl) 46.5 ± 1.0 43.8 ± 1.0 43.8 ± 1.1 0.12
LDL cholesterol (mg/dl) 107.7 ± 2.4 105.3 ± 2.8 101.0 ± 2.6 0.19
Fasting triglycerides (mg/dl) 133.9 ± 5.3 164.6 ± 15.0 170.0 ± 9.9 0.043
Postprandial triglyerides, maximum (mg/dl) 253.5 ± 9.7 305.4 ± 19.7 309.9 ± 14.2 0.015
Postprandial triglycerides, AUC (mg/dl) 943.8 ± 36.2 1135.6 ± 68.5 1160.3 ± 54.4 0.010
C-reactive protein (mg/l) 3.65 ± 0.5 4.90 ± 0.5 4.99 ± 0.7 0.16
  1. Categorical variables are shown as rate (number) and continuous values as mean (SEM). TIA denotes transitory ischemic attack. Active smoking was regular tobacco use at or within 12 months prior to enrolment. Regular alcohol use was consumption of any alcoholic beverage >3 times/week. The HOMA (Homeostasis Model Assessment) index is the fasting glucose concentration (in milligrams per deciliter) multiplied by the fasting insulin concentration (in microunits per milliliter) divided by 405.
  2. *HbA1c was missing in 23 patients.