Table 2 Baseline characteristics, stratified by tertiles of (log)SFRP4
(log) SFRP4 Tertiles | ||||
|---|---|---|---|---|
1 | 2 | 3 | ||
(log)SFRP4 range | <0.99 | 0.99 - 1.11 | >1.11 | p-Value |
Group size | 33.3 (168) | 33.3 (168) | 33.3 (168) | |
Age (years) | 65.2 ± 0.7 | 65.8 ± 0.8 | 68.2 ± 0.8 | 0.017 |
Male | 86.3 (145) | 85.7 (144) | 78.0 (131) | 0.068 |
Medical history | ||||
Previous myocardial infarction | 35.7 (60) | 44.6 (75) | 51.8 (87) | 0.014 |
PCI | 57.1 (96) | 66.7 (112) | 76.8 (129) | 0.001 |
Bypass operation | 7.1 (12) | 14.3 (24) | 16.1 (27) | 0.03 |
Previous stroke or TIA | 6.0 (10) | 12.5 (21) | 13.1 (22) | 0.065 |
Peripheral artery disease | 6.5 (11) | 10.1 (17) | 10.7 (18) | 0.37 |
Clinical characteristics | ||||
Smoking | 21.4 (36) | 20.8 (35) | 14.3 (24) | 0.18 |
Alcohol regularly | 27.4 (46) | 25.0 (42) | 19.0 (32) | 0.18 |
Positive family history | 31.5 (53) | 29.2 (49) | 32.1 (54) | 0.79 |
Arterial hypertension | 88.7 (149) | 94.0 (158) | 95.2 (160) | 0.095 |
Systolic BP (mmHg) | 124.3 ± 1.2 | 127.0 ± 1.2 | 128.2 ± 1.3 | 0.067 |
Diastolic BP (mmHg) | 74.0 ± 0.7 | 74.9 ± 0.7 | 74.8 ± 0.8 | 0.62 |
BMI (kg/m2) | 27.9 ± 0.3 | 29.4 ± 0.3 | 29.3 ± 0.4 | 0.002 |
Waist circumference (cm) | 100.9 ± 0.8 | 104.9 ± 0.9 | 104.9 ± 0.9 | 0.001 |
Waist-to-hip-ratio | 1.00 ± 0.0 | 1.00 ± 0.0 | 1.01 ± 0.0 | 0.36 |
Metabolic characterization | ||||
Normal glucose tolerance | 32.1 (54) | 20.2 (34) | 20.8 (35) | 0.017 |
Impaired glucose tolerance | 29.8 (50) | 28.6 (48) | 26.8 (45) | 0.84 |
Diabetes mellitus | 38.1 (64) | 51.2 (86) | 52.4 (88) | 0.014 |
Metabolic syndrome | 50.6 (85) | 72.0 (121) | 72.0 (121) | <0.0001 |
Fasting glucose (mg/dl) | 118.6 ± 2.5 | 119.5 ± 2.3 | 125.0 ± 2.6 | 0.15 |
Fasting insulin (μIU/ml) | 8.73 ± 0.6 | 11.41 ± 0.9 | 12.69 ± 1.1 | 0.007 |
HOMA index | 2.70 ± 0.24 | 3.64 ± 0.36 | 4.33 ± 0.55 | 0.018 |
HbA1c (%)* | 6.05 ± 0.1 | 6.09 ± 0.1 | 6.40 ± 0.1 | 0.011 |
Total cholesterol (mg/dl) | 175.0 ± 2.8 | 171.2 ± 3.2 | 170.9 ± 3.0 | 0.55 |
HDL cholesterol (mg/dl) | 46.5 ± 1.0 | 43.8 ± 1.0 | 43.8 ± 1.1 | 0.12 |
LDL cholesterol (mg/dl) | 107.7 ± 2.4 | 105.3 ± 2.8 | 101.0 ± 2.6 | 0.19 |
Fasting triglycerides (mg/dl) | 133.9 ± 5.3 | 164.6 ± 15.0 | 170.0 ± 9.9 | 0.043 |
Postprandial triglyerides, maximum (mg/dl) | 253.5 ± 9.7 | 305.4 ± 19.7 | 309.9 ± 14.2 | 0.015 |
Postprandial triglycerides, AUC (mg/dl) | 943.8 ± 36.2 | 1135.6 ± 68.5 | 1160.3 ± 54.4 | 0.010 |
C-reactive protein (mg/l) | 3.65 ± 0.5 | 4.90 ± 0.5 | 4.99 ± 0.7 | 0.16 |