Figure 4
Effect of cariporide on methylglyoxal-induced leukocyte recruitment . (A) Representative intravital microscopy images showing adherent (white arrowheads) and emigrated (black arrowheads) leukocytes. B - E. Means ± SEM (n = 6) of leukocyte rolling flux (cells/min; B), rolling velocity (μM/sec; C), adhesion (cells/100-μM venule; D) and emigration (cells/443 × 286 μM2 field; E) determined 4.0 - 5.5 h after an intrascrotal injection of saline (Control) or MG (50 mg/kg) alone or co-treated with MG and cariporide (20 mg/kg, 1 h prior to MG). * indicates significant difference (p < 0.05) from MG alone.