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Table 1 ANGPTL8 SNPs that are associated with lipid levels

From: A dual role of lipasin (betatrophin) in lipid metabolism and glucose homeostasis: consensus and controversy

rsID

 

rs2278426

rs145464906

Allele

Alleles

C/T

C/T

Ancestral

C

C

Minor allele

T

T

Position

Coordinates

Chr 19:11350488

Chr 19:11350874

Strand

Forward strand

Forward strand

Position in transcript

194

380

Position in CDS

175

361

Position in protein

59

121

Consequence

Consequence

Non-synonymous

Stop gained

Codons

CGG to TGG

CAG to TAG

Amino acids

R to W

Q to Stop

MAF

 

15.2% [26]

<1% [26]

26%, Hispanics; 18%, AA; 5% EA [19]

0.1%, EUA; 0.01%, AFA [27]

Trait/Effect

HDL-C

Lower in AA (P = 2.1  ×  10-4) and Hispanic (P = 0.025) [19]

10 mg/dl higher in EUA (P = 5.1  × 10-11) [27]

14% lower in Mexicans (P = 3.4  × 10-9) [29]

LDL-C

15% lower in AA (P = 0.005) and Hispanics (P = 0.033) [19]

NS

Triglycerides

NS

15% lower in EUA (P = 0.003) [27]

  1. SNP information is based on dbSNP, release 138. AA, African American; AFA, African ancestry; CDS, coding sequence; Chr, chromosome; EA, European American; EUA, European ancestry; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; MAF, minor allele frequency; NS, non-significant; SNP, single nucleotide polymorphism.