Table 1 ANGPTL8 SNPs that are associated with lipid levels

Allele

Alleles

C/T

C/T

Ancestral

C

C

Minor allele

T

T

Position

Coordinates

Chr 19:11350488

Chr 19:11350874

Strand

Forward strand

Forward strand

Position in transcript

194

380

Position in CDS

175

361

Position in protein

59

121

Consequence

Consequence

Non-synonymous

Stop gained

Codons

CGG to TGG

CAG to TAG

Amino acids

R to W

Q to Stop

MAF

15.2% [26]

<1% [26]

26%, Hispanics; 18%, AA; 5% EA [19]

0.1%, EUA; 0.01%, AFA [27]

Trait/Effect

HDL-C

Lower in AA (P = 2.1  ×  10^-4) and Hispanic (P = 0.025) [19]

10 mg/dl higher in EUA (P = 5.1  × 10^-11) [27]

14% lower in Mexicans (P = 3.4  × 10^-9) [29]

LDL-C

15% lower in AA (P = 0.005) and Hispanics (P = 0.033) [19]

NS

Triglycerides

NS

15% lower in EUA (P = 0.003) [27]