Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population

Table 2 Simple regression analysis for log FABP4

	Whole (n = 190)		Male (n = 82)		Female (n = 108)
	r	p	r	p	r	p
Age	0.225	0.002	0.193	0.083	0.314	0.001
Body mass index	0.500	<0.001	0.580	<0.001	0.564	<0.001
Waist circumference	0.518	<0.001	0.642	<0.001	0.518	<0.001
Systolic blood pressure	0.272	<0.001	0.283	0.010	0.329	0.001
Diastolic blood pressure	0.268	<0.001	0.255	0.021	0.329	0.001
Biochemical data
Total cholesterol	0.213	0.003	0.008	0.943	0.282	0.003
LDL cholesterol	0.268	<0.001	0.058	0.606	0.365	<0.001
HDL cholesterol	−0.107	0.143	−0.125	0.263	−0.238	0.013
log Triglycerides	0.157	0.031	0.097	0.385	0.282	0.003
log Glucose	0.137	0.060	0.081	0.467	0.277	0.004
HbA1c	0.046	0.532	0.044	0.695	0.107	0.272
log Insulin	0.388	<0.001	0.380	0.001	0.480	<0.001
log HOMA-R	0.386	<0.001	0.384	<0.001	0.489	<0.001
Creatinine	0.192	0.008	0.448	<0.001	0.305	0.001
eGFR	−0.350	<0.001	−0.397	<0.001	−0.350	<0.001
log BNP	0.126	0.085	0.076	0.500	0.156	0.108
log hsCRP	0.233	0.001	0.312	0.005	0.218	0.024
Echocardiographic parameters
Left atrial dimension	0.251	0.001	0.354	0.001	0.290	0.002
Left atrial volume index	0.231	0.002	0.226	0.050	0.225	0.020
Mean LV wall thickness	0.195	0.007	0.315	0.004	0.401	<0.001
LV end-diastolic dimension	−0.042	0.562	0.069	0.541	−0.082	0.399
LV mass index	0.039	0.596	0.085	0.448	0.105	0.281
LV ejection fraction	0.113	0.121	0.219	0.048	−0.023	0.812
log E/A	−0.178	0.016	−0.173	0.131	−0.279	0.004
E-wave deceleration time	0.006	0.934	−0.013	0.906	0.066	0.497
e’	−0.360	<0.001	−0.434	<0.001	−0.353	<0.001
E/e’	0.353	<0.001	0.361	0.001	0.327	0.001

BNP, brain natriuretic peptide; eGFR, estimated glomerular filtration rate; hsCRP, high-sensitivity C-reactive protein; LV, left ventricle.

ISSN: 1475-2840