Figure 4

Glibenclamide inhibited macrophage infiltration in streptozotocin (STZ) mice after LPS administration. Representative immunohistochemical staining micrographs for CD68 (brown) of the myocardial tissues indicated that LPS induced more macrophage infiltration in STZ diabetic mice, which could be attenuated by glibenclamide (5 mg/kg, i.g, × 14 d) pretreatment. (A–E), Immunohistochemical staining for CD68 ( × 200; n = 3 per group). A: Control, B: STZ, C: LPS, D: STZ + LPS, E: STZ + LPS + Glib 5 mg/kg. *P < 0.05, **P < 0.01 vs control, ^##P < 0.01 vs STZ + LPS. Values are means ± SEM.