Figure 3

Glibenclamide inhibited myocardial apoptosis in streptozotocin (STZ) mice after LPS administration. Representative TUNEL staining micrographs of the myocardial tissues indicated that LPS induced more severe injury in STZ diabetic mice, which could be attenuated by glibenclamide (5 mg/kg, i.g, × 14 d) pretreatment. A–E, TUNEL staining ( × 200; n = 3 per group). A: Control, B: STZ, C: LPS, D: STZ + LPS, E: STZ + LPS + Glib 5 mg/kg. **P < 0.01 vs control, ^#P < 0.05 vs STZ + LPS. Values are means ± SEM.