Figure 2

Morphological analysis of myocardial damage 6 h after LPS administration. Representative light and transmission electron micrographs of the myocardial tissues indicated that LPS induced more severe myocardial injury in streptozotocin (STZ) diabetic mice, which could be attenuated by glibenclamide (5 mg/kg, i.g, × 14 d) pretreatment. A–E, Hematoxylin-eosin stain ( × 200; n = 3 per group). A: Control, B: STZ, C: LPS, D: S TZ + LPS, E: STZ + LPS + Glib 5 mg/kg. a–e, Transmission electron microscopy ( × 12000; n = 3 per group). a: Control, b: STZ, c: LPS, d: STZ + LPS, e: STZ + LPS + Glib 5 mg/kg. Arrow indicates mitochondria vacuolization and myofilament dissolving. M, mitochondria; MF, myofiber.