Skip to main content

Table 5 Association between hsCRP and GGT levels, and metabolic syndrome and Insulin resistance, within selected subgroups

From: High-sensitivity c-reactive protein and gamma-glutamyl transferase levels are synergistically associated with metabolic syndrome in community-dwelling persons

   Metabolic syndrome OR(95% CI). HOMA-IR ≥2.6† OR(95% CI).
   Tertile of hsCRP Tertile of GGT Tertile of hsCRP Tertile of GGT
   1st 2nd 3rd 1st 2nd 3rd 1st 2nd 3rd 1st 2nd 3rd
Characteristics   <0.360 0.360-0.800 >0.800 mg/L <29 29-54 >54 IU/L <0.280 0.280-0.650 >0.650 mg/L <18 18-24 >24 IU/L
Age              
   <65 years 650 1.00 2.13 (1.26-3.59) 3.76 (2.25-6.27) 1.00 2.66 (1.50-4.72) 3.55 (2.00-6.31) 1.00 2.50 (1.44-4.33) 4.50 (2.62-7.72) 1.00 2.47 (1.37-4.45) 3.04 (1.70-5.42)
   ≥65 years 969 1.00 1.21 (0.73-2.03) 1.88 (1.16-3.06) 1.00 1.84 (1.12-3.04) 3.80 (2.31-6.28) 1.00 2.16 (1.12-4.15) 3.87 (2.08-7.19) 1.00 2.16 (1.12-4.15) 3.87 (2.08-7.19)
Alcohol consumption              
   Absent 829 1.00 1.42 (0.83-2.44) 2.27 (1.34-3.85) 1.00 1.94 (1.16-3.25) 3.04 (1.78-5.10) 1.00 1.11 (0.62-1.98) 2.23 (1.29-3.87) 1.00 4.72 (2.47-9.03) 7.41 (3.81-14.4)
   Present 1090 1.00 1.74 (1.07-2.84) 2.91 (1.82-4.66) 1.00 2.65 (1.54-4.58) 4.89 (2.83-8.44) 1.00 4.50 (2.37-8.54) 7.30 (3.88-13.7) 1.00 1.62 (0.93-2.82) 2.66 (1.55-4.55)
Uric acid              
   <5.0 (mean) mg/dL 978 1.00 1.51 (0.87-2.60) 3.21 (1.90-5.40) 1.00 2.39 (4.41-4.05) 3.53 (2.07-6.03) 1.00 1.98 (1.11-3.54) 3.57 (2.03-6.29) 1.00 2.79 (1.59-4.89) 3.46 (1.95-6.14)
   ≥5.0 (mean) mg/dL 941 1.00 1.68 (1.03-2.75) 2.14 (1.33-3.44) 1.00 2.24 (1.32-3.79) 4.04 (2.38-6.85) 1.00 1.68 (1.03-2.75) 2.14 (1.33-3.44) 1.00 2.24 (1.32-3.79) 4.04 (2.38-6.85)
HMW adiponectin              
   <5.03 (median) μg/mL 963 1.00 1.64 (1.02-2.64) 2.74 (1.73-4.32) 1.00 2.63 (1.63-4.23) 3.52 (2.18-5.69) 1.00 2.63 (1.50-4.60) 4.57 (2.66-7.87) 1.00 1.86 (1.11-3.09) 3.23 (1.97-5.30)
   ≥5.03 (median) μg/mL 956 1.00 1.27 (0.71-2.27) 1.53 (0.85-2.75) 1.00 1.79 (0.96-3.34) 3.76 (2.04-6.96) 1.00 1.61 (0.84-3.10) 2.12 (1.11-4.05) 1.00 4.41 (2.07-9.42) 5.09 (2.33-11.1)
Medication‡              
   Absent 1342 1.00 1.76 (1.09-2.85) 3.11 (1.95-4.93) 1.00 2.02 (1.23-3.31) 3.36 (2.06-5.50) 1.00 3.24 (1.87-5.62) 5.73 (3.34-9.84) 1.00 2.39 (1.43-3.97) 3.05 (1.84-5.07)
   Present 577 1.00 1.18 (0.66-2.09) 1.87 (1.07-3.25) 1.00 2.22 (1.24-3.96) 3.55 (1.95-6.44) 1.00 1.12 (0.57-2.19) 2.07 (1.10-3.88) 1.00 2.94 (1.43-6.06) 6.09 (2.94-12.6)
  1. Metabolic syndrome was defined as having three or more of the following conditions: obesity, raised blood pressure, hypertriglyceridemia, low HDL cholesterolemia, and impaired fasting blood glucose. † Insulin resistance was defined as HOMA-IR ≥2.6. ‡Medication was defined as antihypertensive, antilipidemic, or diabetic medication. Each tertile was calculated within sex and then combined to avoid the gender differences. Values adjusted for sex, age, smoking status, alcohol consumption, uric acid, and estimated glomerular filtration rate.