Intracellular Ca2+ regulating proteins in vascular smooth muscle cells are altered with type 1 diabetes due to the direct effects of hyperglycemia

Table 3 Levels of Ca²⁺ Regulatory Proteins are Changed with Diabetes

	STZ-Induced Diabetic Rat Model				DR-BB Diabetic Rat Model
Protein Density (arbitrary units)	Control Aorta	Diabetic Aorta	Control Femoral	Diabetic Femoral	Control Aorta	Diabetic Aorta
SERCA 2	165 ± 4	121 ± 12 *	120 ± 15	81 ± 9 *	108 ± 3	56 ± 2 *
SERCA 3	69 ± 19	60 ± 14	161 ± 13	110 ± 15 *	78 ± 5	38 ± 15 *
IP ₃ R type 1	40 ± 9	19 ± 8 *	213 ± 22	228 ± 28	135 ± 23	42 ± 6 *
IP ₃ R type 2	ND	ND	ND	ND	37 ± 4	18 ± 3 *
RyR	38 ± 5	95 ± 8 *	ND	ND	11 ± 5	72 ± 59

*Indicates a significantly different value when compared to respective controls (p < 0.05)
ND = not done

ISSN: 1475-2840