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Table 3 Levels of Ca2+ Regulatory Proteins are Changed with Diabetes

From: Intracellular Ca2+ regulating proteins in vascular smooth muscle cells are altered with type 1 diabetes due to the direct effects of hyperglycemia

  STZ-Induced Diabetic Rat Model DR-BB Diabetic Rat Model
Protein Density
(arbitrary units)
Control
Aorta
Diabetic
Aorta
Control Femoral Diabetic Femoral Control
Aorta
Diabetic
Aorta
SERCA 2 165 ± 4 121 ± 12 * 120 ± 15 81 ± 9 * 108 ± 3 56 ± 2 *
SERCA 3 69 ± 19 60 ± 14 161 ± 13 110 ± 15 * 78 ± 5 38 ± 15 *
IP 3 R type 1 40 ± 9 19 ± 8 * 213 ± 22 228 ± 28 135 ± 23 42 ± 6 *
IP 3 R type 2 ND ND ND ND 37 ± 4 18 ± 3 *
RyR 38 ± 5 95 ± 8 * ND ND 11 ± 5 72 ± 59
  1. *Indicates a significantly different value when compared to respective controls (p < 0.05)
  2. ND = not done