Figure 6
Ca2+ Regulatory Protein Levels Change with Diabetes. A) Representative immunoblots for the SERCA proteins from control and diabetic DR-BB rat aorta. Each lane was loaded with protein from an individual animal. B) Plot illustrates the decline in aortic protein levels of the SR Ca2+ ATPases (SERCA2 and SERCA3) and the IP3 receptors (type 1 and 2). Diabetes corresponded with a reduction in protein levels for all Ca2+ regulatory proteins in both the STZ and DR-BB animal models, with one exception. The level of SERCA3 did not decline significantly with diabetes in the STZ model. * indicates a significant decline from non-diabetic rats, p < 0.05