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Table 3 Metabolic response during the treadmill test at the end of the study.

From: Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure

  

Sham Operated

(N = 10)

Vehicle Control

(N = 12)

GLPL

(N = 11)

GLPH

(N = 12)

3174L

(N = 13)

3174H

(N = 7)

Plasma Lactate (mM)

Basal

1.7 ± 0.2*

2.7 ± 0.2

1.9 ± 0.2*

1.9 ± 0.2*

2.0 ± 0.2*

2.1 ± 0.1*

 

Peak

2.5 ± 0.2†

3.1 ± 0.4

2.7 ± 0.3†

3.1 ± 0.6†

3.7 ± 0.5†

3.2 ± 0.5†

VO 2 (ml/kg/h)

Basal

949 ± 67

1027 ± 84

1040 ± 110

1117 ± 108

1073 ± 77

872 ± 57

 

Peak

2022 ± 155†

1949 ± 290†

2334 ± 311†

2659 ± 329†

2554 ± 307†

1431 ± 155†#

EC (kg*m)

 

679 ± 127*

253 ± 52

452 ± 58*

547 ± 56*

535 ± 89*

562 ± 167*

EC/Peak Lactate Ratio

 

290 ± 54*

86 ± 18

200 ± 36*

234 ± 44*

163 ± 31*

203 ± 69*

EC/Peak VO 2 Ratio

 

38.0 ± 7.2*

14.0 ± 3.2

23.4 ± 4.2

24.8 ± 4.3*

24.4 ± 5.4

40.4 ± 12.2*

Running Distance (m)

 

266 ± 50*

99 ± 21

177 ± 22

212 ± 21*

220 ± 36*

251 ± 82*

  1. Mean ± SEM. *P < 0.05 versus vehicle-treated group. †P < 0.05 peak versus basal in same group. #P < 0.05 3174L versus 3174H group. VO2, oxygen consumption; EC, exercise capacity.
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Cardiovascular Diabetology

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