Skip to main content

Advertisement

Table 3 Metabolic response during the treadmill test at the end of the study.

From: Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure

   Sham Operated (N = 10) Vehicle Control (N = 12) GLPL (N = 11) GLPH (N = 12) 3174L (N = 13) 3174H (N = 7)
Plasma Lactate (mM) Basal 1.7 ± 0.2* 2.7 ± 0.2 1.9 ± 0.2* 1.9 ± 0.2* 2.0 ± 0.2* 2.1 ± 0.1*
  Peak 2.5 ± 0.2† 3.1 ± 0.4 2.7 ± 0.3† 3.1 ± 0.6† 3.7 ± 0.5† 3.2 ± 0.5†
VO 2 (ml/kg/h) Basal 949 ± 67 1027 ± 84 1040 ± 110 1117 ± 108 1073 ± 77 872 ± 57
  Peak 2022 ± 155† 1949 ± 290† 2334 ± 311† 2659 ± 329† 2554 ± 307† 1431 ± 155†#
EC (kg*m)   679 ± 127* 253 ± 52 452 ± 58* 547 ± 56* 535 ± 89* 562 ± 167*
EC/Peak Lactate Ratio   290 ± 54* 86 ± 18 200 ± 36* 234 ± 44* 163 ± 31* 203 ± 69*
EC/Peak VO 2 Ratio   38.0 ± 7.2* 14.0 ± 3.2 23.4 ± 4.2 24.8 ± 4.3* 24.4 ± 5.4 40.4 ± 12.2*
Running Distance (m)   266 ± 50* 99 ± 21 177 ± 22 212 ± 21* 220 ± 36* 251 ± 82*
  1. Mean ± SEM. *P < 0.05 versus vehicle-treated group. †P < 0.05 peak versus basal in same group. #P < 0.05 3174L versus 3174H group. VO2, oxygen consumption; EC, exercise capacity.