Vascular reactivity experiments with and without perivascular adipose tissue in CD and FRD animals. A. Increase in the maximal force of the second contraction (without PVAT) developed by aortic rings from CD and FRD animals stimulated with 5 μM 5-HT (CD, n = 17; FRD, n = 15) or high-K+ KRB (CD, n = 20; FRD, n = 17). Results are expressed as the increase of the contraction without PVAT compared to a previous contraction with PVAT whose maximal force is taken as 100%. The asterisk indicates a statistically significant difference from the CD group. B. Maximal forces attained by denuded aortic rings (without PVAT) from CD and FRD animals stimulated with 5 μM 5-HT (CD, n = 8; FRD, n = 7) or high-K+ KRB (CD, n = 8; FRD, n = 9).