|
Variable
|
IR (+)
|
IR(-)
|
p-valuea
|
NGT
|
IGT
|
T2DM#
|
p-valuea
|
|---|
|
n (%)
|
38 (18)
|
113 (54)
|
-
|
64 (31)
|
54 (26)
|
90 (43)
|
-
|
|
Variables
| | | | | | | |
|
Age (years)
|
62 (53-72)
|
65 (56-72)
|
0.604
|
62 (54-69)
|
61 (51-70)
|
71 (63-75)
|
< 0.001*
|
|
Female sex, n (%)
|
17 (45)
|
53 (47)
|
0.484
|
30 (46)
|
23 (42)
|
46 (51)
|
0.606
|
|
WC (cm)
|
103 (97-118)
|
100 (92-111)
|
0.031*
|
99 (90-110)
|
100 (95-111)
|
109 (98-117)
|
< 0.001*
|
|
HC (cm)
|
105 (98-114)
|
99 (92-109)
|
0.019*
|
100 (91-109)
|
99 (95-110)
|
109 (100-116)
|
< 0.001*
|
|
BMI (kg/m2)
|
28 (26-35)
|
26 (24-30)
|
0.001*
|
25 (24-30)
|
26 (24-31)
|
29 (26-32)
|
< 0.001*
|
|
SBP, mmHg
|
135 (128-142)
|
130 (120-137)
|
0.020*
|
128 (120-135)
|
130 (126-140)
|
136 (130-142)
|
< 0.001*
|
|
DBP, mmHg
|
80 (75-82)
|
80 (70-82)
|
0.863
|
80 (70-80)
|
80 (74-84)
|
80 (73-84)
|
0.055
|
|
MAP (mmHg)
|
96 (91-101)
|
96 (90-100)
|
0.258
|
94 (87-98)
|
96 (91-101)
|
98 (93-102)
|
0.003*
|
|
Puls-Pressure
|
57 (48-60)
|
50 (42-58)
|
0.031*
|
50 (41-58)
|
52 (44-60)
|
54 (50-61)
|
0.005*
|
|
CV risk factors
| | | | | | | |
|
HTN, n (%)
|
33 (89)
|
95 (84)
|
0.319
|
49 (76)
|
47 (89)
|
84 (95)
|
0.002*
|
|
HLP, n (%)
|
23 (61)
|
73 (64)
|
0.396
|
37 (58)
|
36 (67)
|
62 (70)
|
0.305
|
|
Smoker, n (%)
|
2 (5)
|
21 (19)
|
0.037*
|
12 (19)
|
10 (19)
|
10 (12)
|
0.366
|
|
Family Hx CAD
|
24 (63)
|
59 (52)
|
0.162
|
29 (45)
|
35 (64)
|
42 (27)
|
0.065
|
|
Hx Stroke, n (%)
|
0 (0)
|
4 (3)
|
0.309
|
3 (5)
|
1 (2)
|
4 (4)
|
0.674
|
|
Labaratory data
| | | | | | | |
|
Fasting glucose
|
100 (105-118)
|
92 (86-98)
|
< 0.001*
|
89 (84-94)
|
104 (90-112)
|
105 (98-118)
|
< 0.001*
|
|
2h-PG (mg/dl)
|
183 (138-233)
|
132 (112-161)
|
< 0.001*
|
117 (99-130)
|
156 (139-164)
|
225 (212-248) b
|
< 0.001*
|
|
Insulin (μU/L)
|
18.5 (15.7-24.0)
|
5.0 (3.0-7.0)
|
< 0.001*
|
5.0 (2.0-7.0)
|
8.0 (5.0-15.0)
|
9.5 (6.0-18.0) b
|
< 0.001*
|
|
HOMA-IR
|
5.09 (3.96-6.61)
|
1.2 (0.69-1.77)
|
< 0.001*
|
1.10 (0.44-1.56)
|
1.86 (1.10-3.85)
|
2.53 (1.62-4.78) b
|
<0.001*
|
|
QUICKI
|
0.30 (0.29-0.31)
|
0.37 (0.35-0.40)
|
<0.001*
|
0.38 (0.35-0.44)
|
0.35 (0.31-0.38)
|
0.33 (0.30-0.35) b
|
0.001*
|
|
HbA1c (%)
|
5.9 (5.7-6.3)
|
5.7 (5.5-6.1)
|
0.033*
|
5.7 (5.4-6.0)
|
5.8 (5.6-6.1)
|
6.6 (6.0-7.4)
|
<0.001*
|
|
LDL-Ch (mg/dl)
|
114 (99-136)
|
109 (90-130)
|
0.207
|
109 (92-136)
|
115 (99-130)
|
103 (77-130)
|
0.095
|
|
HDL- Ch (mg/dl)
|
49 (38-57)
|
54 (4566)
|
0.044*
|
54 (46-68)
|
53 (47-63)
|
46 (38-59)
|
0.001*
|
|
Total- Ch (mg/dl)
|
204 (177-222)
|
191 (171-222)
|
0.529
|
189 (175-228)
|
200 (173-220)
|
188 (63-221)
|
0.300
|
|
Triglyceride
|
142 (100-202)
|
124 (90-169)
|
0.234
|
120 (89-157)
|
126 (95-165)
|
162 (118-258)
|
0.001*
|
|
Lipoprotein (a)
|
13 (5-27)
|
14 (5-39)
|
0.729
|
11 (5-35)
|
15 (4-38)
|
5 (13-35)
|
0.944
|
|
Creatinine (mg/dl)
|
0.90 (0.80-1.20)
|
0.89 (0.77-0.98)
|
0.253
|
0.88 (0.75-0.96)
|
0.90 (0.76-1.0)
|
0.79 (0.90-1.05)
|
0.643
|
|
hsCRP (mg/dl)
|
0.2 (0.1-0.5)
|
0.2 (0.1-0.6)
|
0.961
|
0.2 (0.10-0.8)
|
0.2 (0.1-0.45)
|
0.3 (0.2-0.6)
|
0.113
|
- Values are median (interquartile range) or n (%).a Mann-Whitney-Test, Jonckheere-Terpstra test, Fisher or χ2 Test were used as appropriate, b = 33 subjects with new detected diabetes * statistically significant (p < 0,05). # Subjects with diabetes before inclusion or new detected diabetes. BMI = Body mass index, CAD = Coronary Artery Disease, Ch = Cholesterol, CV = Cardiovascuklar, DBP = Diastolic blood pressure, HC = Hip circumference, HLP = Hyperlipidaemia, hsCRP = High sensitive CRP, HTN = Hypertension, Hx = history of, IR = insulin resistance, MAP = mean arterial pressure, PG = Postprandial glucose, SBP = Systolic blood pressure, WC = Waist circumference
