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Table 1 Demographics, clinical variables and laboratory parameters in subjects with or without IR and in different degrees of glucose disturbance disorders

From: Insulin resistance and glycemic abnormalities are associated with deterioration of left ventricular diastolic function: a cross-sectional study

Variable IR (+) IR(-) p-valuea NGT IGT T2DM# p-valuea
n (%) 38 (18) 113 (54) - 64 (31) 54 (26) 90 (43) -
Variables        
Age (years) 62 (53-72) 65 (56-72) 0.604 62 (54-69) 61 (51-70) 71 (63-75) < 0.001*
Female sex, n (%) 17 (45) 53 (47) 0.484 30 (46) 23 (42) 46 (51) 0.606
WC (cm) 103 (97-118) 100 (92-111) 0.031* 99 (90-110) 100 (95-111) 109 (98-117) < 0.001*
HC (cm) 105 (98-114) 99 (92-109) 0.019* 100 (91-109) 99 (95-110) 109 (100-116) < 0.001*
BMI (kg/m2) 28 (26-35) 26 (24-30) 0.001* 25 (24-30) 26 (24-31) 29 (26-32) < 0.001*
SBP, mmHg 135 (128-142) 130 (120-137) 0.020* 128 (120-135) 130 (126-140) 136 (130-142) < 0.001*
DBP, mmHg 80 (75-82) 80 (70-82) 0.863 80 (70-80) 80 (74-84) 80 (73-84) 0.055
MAP (mmHg) 96 (91-101) 96 (90-100) 0.258 94 (87-98) 96 (91-101) 98 (93-102) 0.003*
Puls-Pressure 57 (48-60) 50 (42-58) 0.031* 50 (41-58) 52 (44-60) 54 (50-61) 0.005*
CV risk factors        
HTN, n (%) 33 (89) 95 (84) 0.319 49 (76) 47 (89) 84 (95) 0.002*
HLP, n (%) 23 (61) 73 (64) 0.396 37 (58) 36 (67) 62 (70) 0.305
Smoker, n (%) 2 (5) 21 (19) 0.037* 12 (19) 10 (19) 10 (12) 0.366
Family Hx CAD 24 (63) 59 (52) 0.162 29 (45) 35 (64) 42 (27) 0.065
Hx Stroke, n (%) 0 (0) 4 (3) 0.309 3 (5) 1 (2) 4 (4) 0.674
Labaratory data        
Fasting glucose 100 (105-118) 92 (86-98) < 0.001* 89 (84-94) 104 (90-112) 105 (98-118) < 0.001*
2h-PG (mg/dl) 183 (138-233) 132 (112-161) < 0.001* 117 (99-130) 156 (139-164) 225 (212-248) b < 0.001*
Insulin (μU/L) 18.5 (15.7-24.0) 5.0 (3.0-7.0) < 0.001* 5.0 (2.0-7.0) 8.0 (5.0-15.0) 9.5 (6.0-18.0) b < 0.001*
HOMA-IR 5.09 (3.96-6.61) 1.2 (0.69-1.77) < 0.001* 1.10 (0.44-1.56) 1.86 (1.10-3.85) 2.53 (1.62-4.78) b <0.001*
QUICKI 0.30 (0.29-0.31) 0.37 (0.35-0.40) <0.001* 0.38 (0.35-0.44) 0.35 (0.31-0.38) 0.33 (0.30-0.35) b 0.001*
HbA1c (%) 5.9 (5.7-6.3) 5.7 (5.5-6.1) 0.033* 5.7 (5.4-6.0) 5.8 (5.6-6.1) 6.6 (6.0-7.4) <0.001*
LDL-Ch (mg/dl) 114 (99-136) 109 (90-130) 0.207 109 (92-136) 115 (99-130) 103 (77-130) 0.095
HDL- Ch (mg/dl) 49 (38-57) 54 (4566) 0.044* 54 (46-68) 53 (47-63) 46 (38-59) 0.001*
Total- Ch (mg/dl) 204 (177-222) 191 (171-222) 0.529 189 (175-228) 200 (173-220) 188 (63-221) 0.300
Triglyceride 142 (100-202) 124 (90-169) 0.234 120 (89-157) 126 (95-165) 162 (118-258) 0.001*
Lipoprotein (a) 13 (5-27) 14 (5-39) 0.729 11 (5-35) 15 (4-38) 5 (13-35) 0.944
Creatinine (mg/dl) 0.90 (0.80-1.20) 0.89 (0.77-0.98) 0.253 0.88 (0.75-0.96) 0.90 (0.76-1.0) 0.79 (0.90-1.05) 0.643
hsCRP (mg/dl) 0.2 (0.1-0.5) 0.2 (0.1-0.6) 0.961 0.2 (0.10-0.8) 0.2 (0.1-0.45) 0.3 (0.2-0.6) 0.113
  1. Values are median (interquartile range) or n (%).a Mann-Whitney-Test, Jonckheere-Terpstra test, Fisher or χ2 Test were used as appropriate, b = 33 subjects with new detected diabetes * statistically significant (p < 0,05). # Subjects with diabetes before inclusion or new detected diabetes. BMI = Body mass index, CAD = Coronary Artery Disease, Ch = Cholesterol, CV = Cardiovascuklar, DBP = Diastolic blood pressure, HC = Hip circumference, HLP = Hyperlipidaemia, hsCRP = High sensitive CRP, HTN = Hypertension, Hx = history of, IR = insulin resistance, MAP = mean arterial pressure, PG = Postprandial glucose, SBP = Systolic blood pressure, WC = Waist circumference