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Table 1 Demographics, clinical variables and laboratory parameters in subjects with or without IR and in different degrees of glucose disturbance disorders

From: Insulin resistance and glycemic abnormalities are associated with deterioration of left ventricular diastolic function: a cross-sectional study

Variable

IR (+)

IR(-)

p-valuea

NGT

IGT

T2DM#

p-valuea

n (%)

38 (18)

113 (54)

-

64 (31)

54 (26)

90 (43)

-

Variables

       

Age (years)

62 (53-72)

65 (56-72)

0.604

62 (54-69)

61 (51-70)

71 (63-75)

< 0.001*

Female sex, n (%)

17 (45)

53 (47)

0.484

30 (46)

23 (42)

46 (51)

0.606

WC (cm)

103 (97-118)

100 (92-111)

0.031*

99 (90-110)

100 (95-111)

109 (98-117)

< 0.001*

HC (cm)

105 (98-114)

99 (92-109)

0.019*

100 (91-109)

99 (95-110)

109 (100-116)

< 0.001*

BMI (kg/m2)

28 (26-35)

26 (24-30)

0.001*

25 (24-30)

26 (24-31)

29 (26-32)

< 0.001*

SBP, mmHg

135 (128-142)

130 (120-137)

0.020*

128 (120-135)

130 (126-140)

136 (130-142)

< 0.001*

DBP, mmHg

80 (75-82)

80 (70-82)

0.863

80 (70-80)

80 (74-84)

80 (73-84)

0.055

MAP (mmHg)

96 (91-101)

96 (90-100)

0.258

94 (87-98)

96 (91-101)

98 (93-102)

0.003*

Puls-Pressure

57 (48-60)

50 (42-58)

0.031*

50 (41-58)

52 (44-60)

54 (50-61)

0.005*

CV risk factors

       

HTN, n (%)

33 (89)

95 (84)

0.319

49 (76)

47 (89)

84 (95)

0.002*

HLP, n (%)

23 (61)

73 (64)

0.396

37 (58)

36 (67)

62 (70)

0.305

Smoker, n (%)

2 (5)

21 (19)

0.037*

12 (19)

10 (19)

10 (12)

0.366

Family Hx CAD

24 (63)

59 (52)

0.162

29 (45)

35 (64)

42 (27)

0.065

Hx Stroke, n (%)

0 (0)

4 (3)

0.309

3 (5)

1 (2)

4 (4)

0.674

Labaratory data

       

Fasting glucose

100 (105-118)

92 (86-98)

< 0.001*

89 (84-94)

104 (90-112)

105 (98-118)

< 0.001*

2h-PG (mg/dl)

183 (138-233)

132 (112-161)

< 0.001*

117 (99-130)

156 (139-164)

225 (212-248) b

< 0.001*

Insulin (μU/L)

18.5 (15.7-24.0)

5.0 (3.0-7.0)

< 0.001*

5.0 (2.0-7.0)

8.0 (5.0-15.0)

9.5 (6.0-18.0) b

< 0.001*

HOMA-IR

5.09 (3.96-6.61)

1.2 (0.69-1.77)

< 0.001*

1.10 (0.44-1.56)

1.86 (1.10-3.85)

2.53 (1.62-4.78) b

<0.001*

QUICKI

0.30 (0.29-0.31)

0.37 (0.35-0.40)

<0.001*

0.38 (0.35-0.44)

0.35 (0.31-0.38)

0.33 (0.30-0.35) b

0.001*

HbA1c (%)

5.9 (5.7-6.3)

5.7 (5.5-6.1)

0.033*

5.7 (5.4-6.0)

5.8 (5.6-6.1)

6.6 (6.0-7.4)

<0.001*

LDL-Ch (mg/dl)

114 (99-136)

109 (90-130)

0.207

109 (92-136)

115 (99-130)

103 (77-130)

0.095

HDL- Ch (mg/dl)

49 (38-57)

54 (4566)

0.044*

54 (46-68)

53 (47-63)

46 (38-59)

0.001*

Total- Ch (mg/dl)

204 (177-222)

191 (171-222)

0.529

189 (175-228)

200 (173-220)

188 (63-221)

0.300

Triglyceride

142 (100-202)

124 (90-169)

0.234

120 (89-157)

126 (95-165)

162 (118-258)

0.001*

Lipoprotein (a)

13 (5-27)

14 (5-39)

0.729

11 (5-35)

15 (4-38)

5 (13-35)

0.944

Creatinine (mg/dl)

0.90 (0.80-1.20)

0.89 (0.77-0.98)

0.253

0.88 (0.75-0.96)

0.90 (0.76-1.0)

0.79 (0.90-1.05)

0.643

hsCRP (mg/dl)

0.2 (0.1-0.5)

0.2 (0.1-0.6)

0.961

0.2 (0.10-0.8)

0.2 (0.1-0.45)

0.3 (0.2-0.6)

0.113

  1. Values are median (interquartile range) or n (%).a Mann-Whitney-Test, Jonckheere-Terpstra test, Fisher or χ2 Test were used as appropriate, b = 33 subjects with new detected diabetes * statistically significant (p < 0,05). # Subjects with diabetes before inclusion or new detected diabetes. BMI = Body mass index, CAD = Coronary Artery Disease, Ch = Cholesterol, CV = Cardiovascuklar, DBP = Diastolic blood pressure, HC = Hip circumference, HLP = Hyperlipidaemia, hsCRP = High sensitive CRP, HTN = Hypertension, Hx = history of, IR = insulin resistance, MAP = mean arterial pressure, PG = Postprandial glucose, SBP = Systolic blood pressure, WC = Waist circumference
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Cardiovascular Diabetology

ISSN: 1475-2840