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Figure 11 | Cardiovascular Diabetology

Figure 11

From: Synergism in hyperhomocysteinemia and diabetes: role of PPAR gamma and tempol

Figure 11

A model for diabetic cardiomyopathy. In diabetes, elevated level of homocysteine induces oxidative radicals by antagonizing PPARĪ³ that activates matrix metalloproteinases (MMPs), which in turn causes fibrosis and endothelial-myocytes disconnection. It results into endothelial-myocytes uncoupling that ultimately leads to diastolic dysfunction. PPARĪ³ agonist and anti-oxidants mitigate the effect of oxidative radicals, inhibit the activity of MMPs and thereby ameliorate diastolic dysfunction.

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