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Table 2 Indices (mean ± SD) for glycemic variation with twice-daily Mix 25 vs. Mix 50 regimens in 11 type 2 diabetic patients

From: Continuous glucose monitoring with Humalog Mix 25 versus Humalog Mix 50, twice daily: A comparative pilot study -Results from the Jikei-EValuation of insulin Lispro mixture on pharmacodynamics and glycemic VariancE (J-EVOLVE) study

  Mix 25 regimen Mix 50 regimen P value*
24-hour mean glucose concentration (mg/dL) 176 ± 54 187 ± 41 0.231
SD for 24-hour mean glucose concentration (mg/dL) 50 ± 16 49 ± 11 0.962
Mean glucose concentration 0-8 hrs (mg/dL) 127 ± 52 147 ± 42 0.024
Mean glucose concentration 8-24 hrs (mg/dL) 199 ± 59 206 ± 45 0.514
Lowest glucose concentration (mg/dL) 95 ± 49 105 ± 29 0.464
Peak glucose concentration (mg/dL) 276 ± 62 299 ± 43 0.061
Mean pre-meal glucose concentration (mg/dL)    
   Pre-breakfast 144 ± 54 172 ± 45 0.496
   Pre-lunch 151 ± 72 153 ± 55 0.349
   Pre-supper 161 ± 60 177 ± 60 0.997
Increase in postprandial peak glucose concentration (mg/dL)    
   Post-breakfast 93 ± 35 85 ± 28 0.366
   Post-lunch 113 ± 43 138 ± 46 0.949
   Post-supper 76 ± 28 59 ± 36 0.287
Time to postprandial peak glucose concentration (minutes)    
   Post-breakfast 98 ± 38 93 ± 37 0.667
   Post-lunch 136 ± 34 131 ± 21 0.658
   Post-supper 81 ± 23 71 ± 21 0.358
  1. *t-test