Genetic variation in the adiponectin receptor 2 (ADIPOR2) gene is associated with coronary artery disease and increased ADIPOR2 expression in peripheral monocytes

Table 4 Anthropometric and metabolic characteristics of the study population divided according to the genotypes of rs767870 of the ADIPOR2

rs767870	A/A	A/G	G/G	p	p
SEX (male/female)	40/6	15/2	3/2	0.25^a
Age (years)	58.50 ± 1.29	59.53 ± 1.88	54.80 ± 2.48	0.54
Weight (Kg)	81.73 ± 1.43	86.25 ± 2.74	75.10 ± 3.58	0.078
Height (cm)	1.70 ± 0.01	1.71 ± 0.01	1.63 ± 0.01	0.056
BMI (Kg/m²)	27.97 ± 0.40	29.46 ± 0.82	28.18 ± 1.09	0.198
Waist circumference (cm)	98.23 ± 1.39	103.37 ± 2.55	91.6 ± 3.88	0.040	0.067^b
Hip circumference (cm)	101.52 ± 1.01	104.75 ± 2.34	100.20 ± 2.99	0.278
WHR	0.96 ± 0.01	0.99 ± 0.01	0.91 ± 0.03	0.128
IMT (mm)	1.01 ± 0.05	1.02 ± 0.09	0.65 ± 0.09	0.028 ^c	0.053^d
IMT bulb (mm)	1.26 ± 0.07	1.62 ± 0.21	0.78 ± 0.21	0.019	0.025 ^e
FMD (%)	7.62 ± 0.74	5.09 ± 0.76	16.97 ± 4.54	0.0001	0.002 ^e
HOMA	4.02 ± 0.63	4.42 ± 0.47	5.09 ± 2.81	0.887
Matsuda	2.87 ± 0.24	2.31 ± 0.23	3.12 ± 0.72	0.345
Adiponectin (μg/ml)	12.42 ± 0.73	15.82 ± 2.86	10.19 ± 1.24	0.168
AdipoR2 mRNA (AU)	1.02 ± 0.12	1.16 ± 0.23	0.83 ± 0.10	0.732
AdipoR2 protein (MFI)	69.17 ± 4.80	92.03 ± 14.41	45.20 ± 7.70	0.039	0.008 ^f

Data are means ± SEM, ^achi square test, ^bANOVA for comparison among all three genotype groups adjusted for age and sex, ^cANOVA for comparison among all three genotype groups after logarithmic transformation of values, ^dANOVA for comparison among all three genotype groups adjusted for age and BMI, after logarithmic transformation, ^eANOVA for comparison among all three genotype groups adjusted for age, sex, BMI, WHR and HOMA, ^fANOVA for comparison among all three genotype groups adjusted for age, sex, WHR and HOMA.

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