Network of vascular diseases, death and biochemical characteristics in a set of 4,197 patients with type 1 diabetes (The FinnDiane Study)

Table 2 Correlations within diabetic kidney disease groups

	KDNEG r	Microalbuminuria r	Macroalbuminuria r	ESRD r
Age -- Diastolic blood pressure	0.02	-0.15*	-0.20**	-0.29**
Age -- Systolic blood pressure	0.43	0.35	0.28*	0.06**
Adiponectin -- Age	0.32	0.30	0.08**	-0.01**
Adiponectin -- HDL cholesterol	0.45	0.36	0.21**	0.10**
ApoA-II -- HDL₂ cholesterol	0.13	0.17	0.34**	0.33*
ApoA-II -- Waist	0.16	-0.02*	0.02*	0.05
Total cholesterol -- Education	-0.03	-0.18*	-0.08	-0.01
Serum creatinine -- Adiponectin	0.05	0.03	0.29**	0.18
Serum creatinine -- Diabetes duration	0.07	0.22*	0.17	-0.06
Serum creatinine -- Insulin dose	-0.01	-0.17*	-0.15*	-0.13
Serum creatinine -- SRAGE	0.03	0.05	0.33**	0.40**
Serum creatinine -- 24 h-uAlb	0.06	0.07	0.15	0.44†
CRP -- Age	-0.10	0.09*	0.05*	-0.01
CRP -- Serum potassium	-0.05	0.12*	-0.01	-0.02
CRP -- Waist-hip ratio	0.18	0.34*	0.23	0.22
IDL cholesterol -- LDL cholesterol	0.72	0.63*	0.53**	0.53**
LDL cholesterol -- Education	-0.01	-0.17*	-0.07	0.01
MBL -- 24 h-urine urea	0.08	-0.10*	-0.05	-0.02†
Serum potassium -- Diabetes duration	0.27	0.26	-0.02**	-0.02**
VLDL triglycerides -- 24 h-uAlb	0.07	0.12	0.22*	0.51†
24 h-uAlb -- ApoB	0.07	0.19	0.27**	0.31†
24 h-uAlb -- Total cholesterol	0.02	0.17*	0.23**	0.16†
24 h-uAlb -- HDL cholesterol	-0.06	-0.04	-0.12	-0.46†
24 h-uAlb -- IDL cholesterol	0.06	0.16	0.30**	0.50†
24 h-uAlb -- Triglycerides	0.08	0.13	0.23*	0.50†
24 h-uAlb -- 24 h-urine creatinine	0.11	-0.05*	0.02	-0.36†
24 h-uAlb -- 24 h-urine urea	0.04	-0.06	-0.06	-0.41†

Comparison of the KDNEG subset network against the micro-, macroalbuminuria and ESRD networks. The links were chosen by an automatic network topology algorithm (see Methods for details). The Spearman correlation coefficient (denoted by r) of continuous clinical and biochemical variables was used as the measure of association between the variables. Urine samples were not available from most patients with ESRD (72% missing); the r values presented were obtained from the imputed dataset. The links are sorted alphabetically. *P < 0.01, **P < 0.0001, comparison with KDNEG; † imputed.

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