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Figure 2 | Cardiovascular Diabetology

Figure 2

From: Pioglitazone enhances collateral blood flow in ischemic hindlimb of diabetic mice through an Akt-dependent VEGF-mediated mechanism, regardless of PPARγ stimulation

Figure 2

a. Representative photomicrographs of ischemic muscle sections from pioglitazone+GW9662-treated and from pioglitazone+FP-124-treated diabetic mice stained with antibody directed against CD-31, 28 days after surgery. Positive staining appears in brown. Magnification ×40. Number of vessels per cross section is significantly reduced in pioglitazone+FP-124-treated diabetic mice respect to GW9662-treated diabetic mice. b. Quantification of ischemia-induced angiogenesis 14 and 28 days after surgery. Number of vessels per cross section is significantly reduced in STZ-diabetic, pioglitazone+FP-124-treated and GW1929-treated mice vs STZ-diabetic, pioglitazone+FP-124-treated and GW9662-treated mice (p < 0.01 at 14 days and p < 0.05 at 28 days).

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Cardiovascular Diabetology

ISSN: 1475-2840