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Table 1 Clinical and metabolic parameters of the subjects

From: Combined effects of obesity and type 2 diabetes contribute to increased breast cancer risk in premenopausal women

Parameters Normal weight
(N = 22)
Overweight
(N = 34)
Obese
(N = 34)
Age (years) 38.38 ± 11.54 44.71 ± 6.15 44.13 ± 8.42*
BMI (kg/m2) 22.54 ± 2.34 27.73 ± 2.21* 35.76 ± 3.48
Systolic BP (mmHg) 119.86 ± 14.26 127.53 ± 29.81 130.63 ± 15.78*
Diastolic BP (mmHg) 78.76 ± 9.15 76.82 ± 10.58 82.67 ± 12.77
Waist (cm) 90.0 ± 8.98 91.45 ± 8.52 107.57 ± 10.21*
Hips (cm) 92.86 ± 7.31 97.48 ± 8.23 107.0 ± 14.24*
Glucose (mmol/L) 7.28 ± 3.4 8.49 ± 3.86 8.13 ± 4.1
Insulin (μIU/ml)# 15.19 (1.83–42.75) 16.2 (0.51–42.25) 18.82 (2.45–55.82)
HOMA-IR # 5.46 (0.33–22.23) 5.91 (0.17–14.68) 7.0 (0.19–43.66)
Total cholesterol (mmol/L) 4.93 ± 0.92 4.84 ± 1.07 4.7 ± 1.3
LDL-cholesterol (mmol/L) 2.96 ± 0.75 2.77 ± 0.71 2.81 ± 1.01
HDL-cholesterol (mmol/L) 1.26 ± 0.34 1.22 ± 0.37 1.22 ± 0.32
Triglycerides (mmol/L)# 1.33 (0.5–3.04) 1.79 (0.43–7.41) 2.01 (0.43–20.49)
Leptin (ng/ml)# 16.4 (3.2–45.90) 24.86 (1.27–77.60) 35.28 (4.04–120)*
Adiponectin (μg/ml)# 7.6 (2.39–16.90) 4.6 (1.72–9.39)* 4.7 (1.9–7.95) *
CRP (μg/ml)# 2.3 (0–13.30) 5.2 (0–205.0) 6.9 (0.07–34.20)*
TNF-α (pg/ml) 4.8 ± 1.88 4.7 ± 2.0 4.5 ± 1.6
IL-6 (pg/ml)# 4.6 (0.07–10.34) 4.9 (0.11–24.1) 8.3 (0.28–45.30)*
TGF-α (pg/ml)# 13.8 (7.9–42.34) 11.6 (7.0–28.58) 12.3 (7.9–23.01)
  1. Data presented as mean ± SD; parameters marked # indicate median (range); * denotes significance compared to normal weight group; ¶denotes significance compared to normal and over weight groups. ¶*P < 0.05