Table 3 Effective concentration (EC, nM) at 20%, 50% and 80% of maximum angiotensin II contracture in aortas isolated from normoglycemic (group N), in vivo losartan treated normoglycemic (group NL), diabetic (group D), and in vivo losartan treated diabetic rats (group DL) in control condition and in the presence of irbesartan 1 μM and 1 μM irbesartan plus 1 μM PD123319.
EC 20% (nM) | |||
|---|---|---|---|
N | 3.4 ± 0.77 | 3.2 ± 0.67 | NC |
NL | 3.3 ± 0.50 | 4.7 ± 0.72 | NC |
D | 4.4 ± 0.81 | 4.7 ± 1.01 | 3.5 ± 0.86 |
DL | 3.6 ± 0.70 | 4.0 ± 0.88 | 4.1 ± 0.90 |
EC 50% (nM) | |||
N | 22.4 ± 3.88 | 22.1 ± 3.47 | NC |
NL | 19.8 ± 1.16 | 28.1 ± 9.79 | NC |
D | 19.6 ± 2.22 | 18.3 ± 2.49 | 23.2 ± 3.06 |
DL | 22.7 ± 2.10 | 25.9 ± 4.85 | 18.3 ± 2.14 |
EC 80% (nM) | |||
N | 106.6 ± 19.64 | 121.9 ± 21.30 | 263.8 ± 68.43 |
NL | 117.8 ± 27.60 | 128.1 ± 5475 | 170.7 ± 11.02 |
D | 118.4 ± 39.79 | 117.8 ± 30.41 | 215.5 ± 81.48 |
DL | 98.5 ± 29.96 | 160.1 ± 18.72 | 277.6 ± 99.14 |